Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Main Spinal Twine Astrocytoma.
World Neurosurg. 2018 Feb;110:e715-e726
Authors: Inoue T, Endo T, Nakamura T, Shibahara I, Endo H, Tominaga T
OBJECTIVE: Spinal twine astrocytoma with intracranial dissemination carries a poor prognosis. The mechanisms resulting in dissemination stay to be elucidated. A stem cell marker, CD133, was reported to foretell recurrence patterns in intracranial glioblastoma. We evaluated the importance of CD133 as a putative prognostic biomarker to foretell intracranial dissemination in spinal twine astrocytoma.
METHODS: This research included 14 consecutive sufferers with main spinal twine astrocytoma handled from 1998 to 2014. Six of the sufferers have been ladies and the sufferers’ ages ranged from 12 to 75 years. Seven and 6 sufferers underwent open biopsy and partial resection of the tumors, respectively. After affirmation of the histologic diagnoses, all sufferers have been handled with postoperative radiotherapy, chemotherapy, or a mix of each. To establish elements predictive of intracranial dissemination, we analyzed their medical information together with Ki-67 labeling index, and CD133 expression.
RESULTS: Intracranial dissemination was noticed in 6 of 14 sufferers. All 6 sufferers died in the course of the follow-up interval. Of the eight sufferers with out intracranial dissemination, 5 survived (P = zero.02). Median survival for the sufferers with intracranial dissemination was 22.7 months. CD133 expression was considerably increased in sufferers with intracranial dissemination (P = zero.04), whereas different variables didn’t point out the dissemination.
CONCLUSIONS: The expression of CD133 might be an environment friendly biomarker to foretell intracranial dissemination in spinal twine astrocytoma. Recognition of excessive CD133 expression in surgical specimens and early detection of intracranial dissemination is vital for the medical administration of spinal twine astrocytoma.
PMID: 29180077 [PubMed – indexed for MEDLINE]