This article reviews the current research on intervertebral disc repair, focusing on the potential therapeutic role of exosomes derived from mesenchymal stem cells (MSCs) in the repair of intervertebral disc degeneration (IVDD). IVDD is a serious condition causing low back pain and spinal canal stenosis, and current treatment methods such as surgery have limitations. Previous studies have shown that MSC-derived micro-RNAs (miRNAs) in exosomes have therapeutic effects on various components of the intervertebral disc. MiRNAs play a role in cell activities such as proliferation and apoptosis, making them potentially useful in combination with stem cell therapy. The article highlights the molecular biological mechanisms of miRNAs in MSC-derived exosomes in intervertebral disc repair
Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : the highest rated spine centre on Harley Street UK
Published article
Intervertebral disc degeneration (IVDD) is a serious condition that manifests as low back pain, intervertebral disc protrusion, and spinal canal stenosis. At present, the main treatment methods for IVDD are surgical interventions such as discectomy, total disc replacement, and spinal fusion. However, these interventions have shown limitations, such as recurrent lumbar disc herniation after discectomy, lesions in adjacent segments, and failure of fixation. To overcome these shortcomings,…
Lumbar Disc Replacement Surgery Expert. Best Spinal Surgeon UK
Abstract Intervertebral disc degeneration (IVDD) is a serious condition that manifests as low back pain, intervertebral disc protrusion, and spinal canal stenosis. At present, the main treatment methods for IVDD are surgical interventions such as discectomy, total disc replacement, and spinal fusion. However, these interventions have shown limitations, such as recurrent lumbar disc herniation after,
Abstract
Intervertebral disc degeneration (IVDD) is a serious condition that manifests as low back pain, intervertebral disc protrusion, and spinal canal stenosis. At present, the main treatment methods for IVDD are surgical interventions such as discectomy, total disc replacement, and spinal fusion. However, these interventions have shown limitations, such as recurrent lumbar disc herniation after discectomy, lesions in adjacent segments, and failure of fixation. To overcome these shortcomings, researchers have been exploring stem cell transplantation therapy, such as mesenchymal stem cell (MSC) transplantation, but the treatment results are still controversial. Therefore, researchers are in search of new methods that are more efficient and have better outcomes. The exosomes from stem cells contain a variety of bioactive molecules that mediate cell interactions, and these components have been investigated for their potential therapeutic role in the repair of various tissue injuries. Recent studies have shown that MSC-derived miRNAs in exosomes and vesicles have therapeutic effects on nucleus pulposus cells, annulus fibrosus, and cartilage endplate. miRNAs play a role in many cell activities, such as cell proliferation, apoptosis, and cytokine release, by acting on mRNA translation, and they may have immense therapeutic potential, especially when combined with stem cell therapy. This article reviews the current status of research on intervertebral disc repair, especially with regard to the latest research findings on the molecular biological mechanisms of miRNAs in MSC-derived exosomes in intervertebral disc repair.
Keywords: Exosomes; Intervertebral disc degeneration; Mesenchymal stem cells; cartilage endplate; micro-RNA; proliferation.
The London Spine Unit : the highest rated spine centre on Harley Street UK
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Exosome-mediated repair of intervertebral disc degeneration: The potential role of miRNAs
