Ethoxyquin supplies neuroprotection in opposition to cisplatin-induced neurotoxicity.
Sci Rep. 2016 06 28;6:28861
Authors: Zhu J, Carozzi VA, Reed N, Mi R, Marmiroli P, Cavaletti G, Hoke A
Ethoxyquin was just lately recognized as a neuroprotective compound in opposition to poisonous neuropathies and efficacy was demonstrated in opposition to paclitaxel-induced neurotoxicity in vivo. On this examine we examined the efficacy of ethoxyquin in stopping neurotoxicity of cisplatin in rodent fashions of chemotherapy-induced peripheral neuropathy and explored its mechanism of motion. Ethoxyquin prevented neurotoxicity of cisplatin in vitro in a sensory neuronal cell line and first rat dorsal root ganglion neurons. In vivo, power co-administration of ethoxyquin partially abrogated cisplatin-induced behavioral, electrophysiological and morphological abnormalities. Moreover, ethoxyquin didn’t intervene with cisplatin’s skill to induce tumor cell demise in ovarian most cancers cell line in vitro and in vivo. Lastly, ethoxyquin decreased the degrees of two shopper proteins (SF3B2 and ataxin-2) of a chaperone protein, warmth shock protein 90 (Hsp90) when co-administered with cisplatin in vitro. These outcomes implied that the neuroprotective impact of ethoxyquin is mediated by means of these two shopper proteins of Hsp90. The truth is, decreasing ranges of SF3B2 in tissue-cultured neurons was efficient in opposition to neurotoxicity of cisplatin. These findings counsel that ethoxyquin or different compounds that inhibit chaperone exercise of Hsp90 and scale back ranges of its shopper protein, SF3B2 could also be developed as an adjuvant remedy to stop neurotoxicity in cisplatin-based chemotherapy protocols.
PMID: 27350330 [PubMed – indexed for MEDLINE]