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Ersin Arslan City Hospital, Department of Neurosurgery, Gaziantep, Türkiye – Lumbar Spinal Stenosis

The article investigates the impact of biofilm-forming ability of Staphylococcus aureus on treatment outcomes in rats with titanium implants. The study divided rats into groups inoculated with biofilm-forming and non-biofilm-forming strains of S. aureus. Results showed that the presence of biofilm-forming bacteria had a significant effect on infection levels and treatment outcomes. The study suggests that in cases of implant-related infections, checking for the presence of biofilm-forming bacteria early on could guide treatment decisions, potentially avoiding the need for implant removal in certain cases. Further research with different bacterial species is recommended for conclusive results

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

CONCLUSION: The results obtained in the present study reveal that in case of implant-dependent infection, the first sample taken can be checked for slime factor, and if there is infection with slime factor-negative bacterium, treatment without removing the implant may be recommended. S. aureus was used in the study because it is the most common cause of implant-related infection at surgical sites. Further studies using different bacterial species are needed to reach a definitive conclusion.

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Turk Neurosurg. 2023 May 29. doi: 10.5137/1019-5149.JTN.43753-23.1. Online ahead of print. ABSTRACT AIM: The view that the biofilm layer formed on the implant surface is the main cause of treatment failure is more prominent. However, it is known that every bacterium has strains that can and cannot form biofilms. In this study, biofilm-forming and non-biofilm-forming,

Turk Neurosurg. 2023 May 29. doi: 10.5137/1019-5149.JTN.43753-23.1. Online ahead of print.

ABSTRACT

AIM: The view that the biofilm layer formed on the implant surface is the main cause of treatment failure is more prominent. However, it is known that every bacterium has strains that can and cannot form biofilms. In this study, biofilm-forming and non-biofilm-forming strains of Staphylococcus aureus (S. aureus) were used to investigate the effect of the biofilm-forming ability of the bacteria on treatment in rats.

MATERIAL AND METHODS: Forty rats were divided into four equal groups as Group 1A, 1B, 2A, and 2B. All rats underwent single distance lumbar laminectomy, and titanium implants were introduced. Group 1 rats were inoculated with Slime factor (-) S. aureus, while Group 2 rats were inoculated with biofilm Slime factor (+) S. aureus. None of the rats were given antibiotics. One week later, the surgical field was reopened and microbiological samples were taken. The implants of rats in Groups 1A and 2A were left in place, while the implants of rats in Groups 1B and 2B were removed.

RESULTS: There was no statistically significant difference between the groups inoculated with slime factor (+) S. aureus; although, Groups 1A and 2A showed statistically significant difference. Statistical analysis with respect to bacterial count also showed a statistically significant difference between Groups 1A and 2A. There was a statistically significant difference between Group 1B and 2B.

CONCLUSION: The results obtained in the present study reveal that in case of implant-dependent infection, the first sample taken can be checked for slime factor, and if there is infection with slime factor-negative bacterium, treatment without removing the implant may be recommended. S. aureus was used in the study because it is the most common cause of implant-related infection at surgical sites. Further studies using different bacterial species are needed to reach a definitive conclusion.

PMID:38650565 | DOI:10.5137/1019-5149.JTN.43753-23.1

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Ersin Arslan City Hospital, Department of Neurosurgery, Gaziantep, Türkiye

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Turk Neurosurg. 2023 May 29. doi: 10.5137/1019-5149.JTN.43753-23.1. Online ahead of print. ABSTRACT AIM: The view that the biofilm layer formed on the implant surface is the main cause of treatment failure is more prominent. However, it is known that every bacterium has strains that can and cannot form biofilms. In this study, biofilm-forming and non-biofilm-forming
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