Efficacy of statins for osteoporosis: a scientific assessment and meta-analysis.
Osteoporos Int. 2017 Jan;28(1):47-57
Authors: An T, Hao J, Solar S, Li R, Yang M, Cheng G, Zou M
Our meta-analysis assessed the efficacy of statins on the chance of fracture, bone mineral density (BMD), and the markers of bone metabolism by accumulating knowledge from 33 scientific trials. We discovered that statin therapy was related to bone metabolism. And statins appeared to be simpler on male sufferers with osteoporosis. The efficacy of statins for the therapy of osteoporosis has been controversial in earlier research and meta-analyses. Our meta-analysis was carried out to look at intimately the efficacy of statins on osteoporosis. We searched PubMed, Embase, and the Cochrane Library databases for scientific trials from inception to Might 2016. We included research that described the impact of statins on the chance of fracture, BMD, or bone turnover markers. Furthermore, we additionally carried out subgroup analyses based on the skeleton web site, affected person gender, and size of follow-up. A complete of 33 research which included 23 observational research (16 cohort research and seven case-control research) and 10 randomized managed trials (RCTs) had been evaluated. These 33 research included 314,473 sufferers in statin group and 1,349,192 sufferers in management group. Statins decreased the chance of general fractures (OR = Zero.81, 95% CI Zero.73-Zero.89) and hip fractures (OR = Zero.75, 95% CI Zero.60-Zero.92). Moreover, using statins was related to elevated BMD on the whole hip (standardized imply distinction (SMD) = Zero.18, 95% CI Zero.00-Zero.36) and lumbar backbone (SMD = Zero.20, 95% CI Zero.07-Zero.32) and improved the bone formation marker, osteocalcin (OC) (SMD = Zero.21, 95% CI Zero.00-Zero.42). Nonetheless, there was no constructive impact on vertebral fractures, higher extremity fractures, BMD on the femoral neck, bone-specific alkaline phosphatase (BALP), and serum C-terminal peptide of kind I collagen (S-CTX). Additionally, in contrast with male subgroups, the impact on feminine subgroups was solely barely constructive or of no statistical significance. Our meta-analysis signifies that statin therapy could also be related to a decreased threat of general fractures and hip fractures, an elevated BMD on the whole hip, BMD on the lumbar backbone, and OC. Furthermore, our outcomes additionally present that statin therapy could have a larger impact on male sufferers than on feminine sufferers.
PMID: 27888285 [PubMed – indexed for MEDLINE]