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Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion – Lumbar Spinal Stenosis

The article published in Orthopedics explores the use of liposomal bupivacaine in open posterior lumbar decompression and fusion procedures to reduce the reliance on opioid medication for postoperative pain control. A retrospective chart review of 198 patients was conducted, with half of them receiving liposomal bupivacaine intraoperatively. The study found that patients who received liposomal bupivacaine required significantly less morphine milligram equivalents of narcotic medications during their hospital stay, highlighting the potential benefits of this modality in enhancing pain management for patients undergoing posterior lumbar surgery

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].

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Orthopedics. 2024 Apr 4:1-5. doi: 10.3928/01477447-20240325-07. Online ahead of print. ABSTRACT BACKGROUND: Despite improvements in drug therapy and treatment of lumbar spinal disorders, dependence on opioid medication for postoperative pain control remains a concern nationwide. This study assessed the ability to diminish the reliance on opioid medication postoperatively with the Food and Drug Administration-approved local,

Orthopedics. 2024 Apr 4:1-5. doi: 10.3928/01477447-20240325-07. Online ahead of print.

ABSTRACT

BACKGROUND: Despite improvements in drug therapy and treatment of lumbar spinal disorders, dependence on opioid medication for postoperative pain control remains a concern nationwide. This study assessed the ability to diminish the reliance on opioid medication postoperatively with the Food and Drug Administration-approved local anesthetic liposomal bupivacaine in open posterior lumbar decompression and fusion procedures. In addition, the possible effects of this modality on other parameters were studied regarding patients and their recovery.

MATERIALS AND METHODS: A retrospective chart review of 198 patients who underwent an open posterior lumbar laminectomy and fusion surgery with instrumentation treated by a single surgeon in a single institution was conducted. Ninety-nine patients who received liposomal bupivacaine administered intraoperatively were then matched by age, sex, and procedure with the same number of patients treated prior to the availability of liposomal bupivacaine. We evaluated how the use of liposomal bupivacaine affected the requirement for postoperative opioid medication, as well as related changes in length of stay, the use of antiemetics, and urinary retention postoperatively.

RESULTS: The patients who received liposomal bupivacaine required less than half of the morphine milligram equivalents of narcotic medications during their hospital stay compared with patients who did not receive liposomal bupivacaine (approximately 57% reduction).

CONCLUSION: The findings of this study suggest that the addition of liposomal bupivacaine to traditional pain management modalities can augment pain management for patients undergoing posterior lumbar surgery, as evidenced by the significant decrease in postoperative morphine milligram equivalents required. [Orthopedics. 202x;4x(x):xx-xx.].

PMID:38568003 | DOI:10.3928/01477447-20240325-07

The London Spine Unit : most advanced treatment hospital on Harley Street UK

Read the original publication:

Efficacy of Liposomal Bupivacaine in Reducing Opioid Use After Posterior Lumbar Spinal Decompression and Fusion

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Orthopedics. 2024 Apr 4:1-5. doi: 10.3928/01477447-20240325-07. Online ahead of print. ABSTRACT BACKGROUND: Despite improvements in drug therapy and treatment of lumbar spinal disorders, dependence on opioid medication for postoperative pain control remains a concern nationwide. This study assessed the ability to diminish the reliance on opioid medication postoperatively with the Food and Drug Administration-approved local

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