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Efficacy of gelatin-thrombin matrix sealants for blood loss in single-level transforaminal lumbar interbody fusion – Lumbar Fusion

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The article titled “Efficacy of Gelatin-Thrombin Matrix Sealants for Reducing Blood Loss in Single-Level Transforaminal Lumbar Interbody Fusion” examines the effectiveness of gelatin-thrombin matrix sealants in reducing blood loss during single-level transforaminal lumbar interbody fusion surgery for lumbar degenerative disease. The study analyzed 102 patients and compared various factors such as body mass index, surgical time, intraoperative blood loss, postoperative blood loss, and blood pressure between patients who received the sealants and those who did not. The results showed that patients who received the sealants had significantly lower intraoperative, true total, and hidden blood loss, as well as a smaller epidural hematoma size and shorter hospitalization duration. The study concludes that the use of gelatin-thrombin matrix sealants can effectively reduce perioperative blood loss in this type of surgery

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

Although gelatin-thrombin matrix sealants have been used successfully in other surgery types, their effect on reducing blood loss during single-level transforaminal lumbar interbody fusion is unclear. We thus examined the efficacy of gelatin-thrombin matrix sealants for reducing blood loss during such surgery. We analyzed 102 patients who underwent single-level transforaminal lumbar interbody fusion for lumbar degenerative disease. We compared body mass index, surgical time, intraoperative blood…

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Medicine (Baltimore). 2023 Sep 8;102(36):e34667. doi: 10.1097/MD.0000000000034667.ABSTRACTAlthough gelatin-thrombin matrix sealants have been used successfully in other surgery types, their effect on reducing blood loss during single-level transforaminal lumbar interbody fusion is unclear. We thus examined the efficacy of gelatin-thrombin matrix sealants for reducing blood loss during such surgery. We analyzed 102 patients who underwent single-level,

Medicine (Baltimore). 2023 Sep 8;102(36):e34667. doi: 10.1097/MD.0000000000034667.

ABSTRACT

Although gelatin-thrombin matrix sealants have been used successfully in other surgery types, their effect on reducing blood loss during single-level transforaminal lumbar interbody fusion is unclear. We thus examined the efficacy of gelatin-thrombin matrix sealants for reducing blood loss during such surgery. We analyzed 102 patients who underwent single-level transforaminal lumbar interbody fusion for lumbar degenerative disease. We compared body mass index, surgical time, intraoperative blood loss, postoperative blood loss, true total blood loss, hidden blood loss, the proportion of blood transfusion, blood pressure pre- and post-surgery (systolic and diastolic), and pre-and post-surgery laboratory data (hemoglobin, hematocrit, platelets, prothrombin time, activated partial thromboplastin time, and D-dimer) between patients in whom gelatin-thrombin matrix sealants were (GTMS group) or were not (control group) used during surgery. One-week postoperative epidural hematoma size was measured using magnetic resonance imaging. The GTMS and control groups included 54 (24 males and 30 females) and 48 patients (19 males and 29 females). Intraoperative, true total, and hidden blood loss; epidural hematoma size; and hospitalization duration were significantly lower in the GTMS than in the control group. Intraoperative blood loss correlated with surgical time (R = 0.523, P = .001), body mass index (R = 0.221, P = .036), and the amount of gelatin-thrombin matrix sealant used (r = -0.313, P = .002). In multivariate linear regression analysis using intraoperative blood loss as the dependent variable, surgical time (standardization coefficient 0.516, P = .001) and amount of gelatin-thrombin matrix sealant used (standardization coefficient -0.220, P = .032) were independently related factors. In our study, the GTMS group had significantly less intraoperative true total and hidden blood loss than did the control group. Thus, use of gelatin-thrombin matrix sealants reduce perioperative blood loss in transforaminal lumbar interbody fusion.

PMID:37682173 | DOI:10.1097/MD.0000000000034667

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Efficacy of gelatin-thrombin matrix sealants for blood loss in single-level transforaminal lumbar interbody fusion

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Medicine (Baltimore). 2023 Sep 8;102(36):e34667. doi: 10.1097/MD.0000000000034667.ABSTRACTAlthough gelatin-thrombin matrix sealants have been used successfully in other surgery types, their effect on reducing blood loss during single-level transforaminal lumbar interbody fusion is unclear. We thus examined the efficacy of gelatin-thrombin matrix sealants for reducing blood loss during such surgery. We analyzed 102 patients who underwent single-level

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