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Efficacy of Epidural Perineural Injection Of Autologous Conditioned Serum In Unilateral Cervical Radiculopathy: A Pilot study.

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Efficacy of Epidural Perineural Injection Of Autologous Conditioned Serum In Unilateral Cervical Radiculopathy: A Pilot study.

Spine (Phila Pa 1976). 2015 Apr 14;

Authors: Goni VG, Singh Jhala S, Gopinathan NR, Behera P, Batra YK

STUDY DESIGN: Prospective randomized pilot studyObjective. Evaluation of the efficacy of epidural perineural injection of autologous conditioned serum (ACS) vs. methylprednisone (MPS) in unilateral cervical radiculopathy patients.
SUMMARY OF BACKGROUND DATA: Cervical radiculopathy is often treated by non operative and operative means. Guided injections of steroids have been used previously. We used ACS, an orthobiologic derived from patients own blood in patients of unilateral cervical radiculopathy.
METHODS: 40 patients were equally allocated into ACS and MPS groups and were injected with 2.5-3 ml of ACS or MPS respectively under image guidance into the perineural area of the affected nerve root. They were followed up for 6 months with Visual Analogue Scale (VAS) for pain, Neck Pain Disability scale (NPDS) in hindi language, neck disability index (NDI) and Short Form of Health Survey – 12 (SF-12).
RESULTS: Patients who had received injections of ACS and MPS both had improvements in the scores of the evaluation tools. The improvement in the ACS patients was gradual and sustained over the entire study period while that in the MPS group had some deterioration over time. No major complications were noted amongst the two groups. Minor complications were noted in both the groups.
CONCLUSIONS: ACS can be considered an equally good or better modality of non operative management in patients of unilateral cervical radiculopathy as methyl prednisone. The safety profile is good and the improvement seen is sustained over time. Thus it may be offered to affected patients before offering them surgery.

PMID: 25893359 [PubMed – as supplied by publisher]

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