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Effects of nano red elemental selenium on sodium currents in rat dorsal root ganglion neurons

Nano red elemental selenium (Nano-Se), was demonstrated to be useful in medical and scientific researches. Here, we investigated the effects of Nano-Se on sodium currents on rat dorsal root ganglion neurons (DRG), using the whole-cell patch clamp method. Nano-Se reversibly decrease the I(Na)(TTX-S) in a concentration-dependent, time-dependent and open-channel block manners without affecting I(Na)(TTX-R). It shifted the steady-state activation and inactivation curves for I(Na) to more negative potentials. In the research of recovery from inactivation, the recovery time constant is longer in the present of Nano-Se. Nano-Se had a weaker inhibitory effect on I(Na), compared with marked decrease caused by selenite which indicated that Nano-Se is less neurotoxic than selenite in short-term/large dose treatments and had similar bio availability to sodium selenite. The results of interaction between the effects of Nano-Se and selenite on sodium currents indicated a negative allosteric interaction between the selenite binding site and the Nano-Se binding site or that they have the same competitive binding site

Keywords : administration & dosage,Animals,Cells,Cultured,China,Dose-Response Relationship,Drug,drug effects,Ganglia,Spinal,Ion Channel Gating,Membrane Potentials,metabolism,Nanostructures,Neurons,physiology,Posterior Horn Cells,Rats,Rats,Sprague-Dawley,Selenium,Sodium,Sodium Channels,Time,, Nano,Red,Elemental,Selenium, back pain management doctors

Date of Publication : 2006

Authors : Yuan H;Lin J;Lan T;

Organisation : Bioinformation & Control Institute, Huazhong University of Science & Technology, Hubei, China

Journal of Publication : Conf Proc IEEE Eng Med Biol Soc

Pubmed Link :

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