19 Harley St, London, W1G 9QJ, UK

Effects of nano red elemental selenium on sodium currents in rat dorsal root ganglion neurons

Nano red elemental selenium (Nano-Se), was demonstrated to be useful in medical and scientific researches. Here, we investigated the effects of Nano-Se on sodium currents on rat dorsal root ganglion neurons (DRG), using the whole-cell patch clamp method. Nano-Se reversibly decrease the I(Na)(TTX-S) in a concentration-dependent, time-dependent and open-channel block manners without affecting I(Na)(TTX-R). It shifted the steady-state activation and inactivation curves for I(Na) to more negative potentials. In the research of recovery from inactivation, the recovery time constant is longer in the present of Nano-Se. Nano-Se had a weaker inhibitory effect on I(Na), compared with marked decrease caused by selenite which indicated that Nano-Se is less neurotoxic than selenite in short-term/large dose treatments and had similar bio availability to sodium selenite. The results of interaction between the effects of Nano-Se and selenite on sodium currents indicated a negative allosteric interaction between the selenite binding site and the Nano-Se binding site or that they have the same competitive binding site

Keywords : administration & dosage,Animals,Cells,Cultured,China,Dose-Response Relationship,Drug,drug effects,Ganglia,Spinal,Ion Channel Gating,Membrane Potentials,metabolism,Nanostructures,Neurons,physiology,Posterior Horn Cells,Rats,Rats,Sprague-Dawley,Selenium,Sodium,Sodium Channels,Time,, Nano,Red,Elemental,Selenium, back pain management doctors

Date of Publication : 2006

Authors : Yuan H;Lin J;Lan T;

Organisation : Bioinformation & Control Institute, Huazhong University of Science & Technology, Hubei, China

Journal of Publication : Conf Proc IEEE Eng Med Biol Soc

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/17945607

The London Spine Unit : Harley Street UK. Specialists in Cutting Edge Technologies for Spinal Surgery

Make an Appointment 

Trustpilot Reviews
Doctify Reviews
Top Doctor Reviews

Effects of nano red elemental selenium on sodium currents in rat dorsal root ganglion neurons | Harley street doctors london

What our patients say ...

Consultant Spine Surgeon
Consultant Spine Surgeon
Consultant Spine Surgeon

This surgical technique consists of a percutaneous approach for the treatment of small to medium size hernias of the intervertebral disc by laser energy. The main objective is to reduce the intradiscal pressure in the nucleus pulposus

Laser Disc Surgery can be performed under local anaesthetic as a day case at our centre on the prestigious Harley Street.
What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

treatment of all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810