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Effects of epidural TNF-alpha inhibitor injection: analysis of the pathological changes in a rat model of chronic compression of the dorsal root ganglion

OBJECTIVES: To evaluate the efficacy of a single direct epidural injection of tumor necrosis factor (TNF)-alpha inhibitor to reduce the pathological changes in nerve fiber injuries in a rat model of chronic compression of the dorsal root ganglion (CCD). MATERIALS AND METHODS: A surgical procedure for CCD was performed in 17 adult male F-344 rats. The effects of the epidural TNF-alpha inhibitors on CCD-induced pathological changes were investigated. Three groups of rats (n = 17) were used: (1) CCD + saline (n = 4), (2) CCD + triamcinolone (n = 5), and (3) CCD + TNF-alpha inhibitors (n = 8). Their dorsal root ganglia and nerve roots were removed on postoperative day 14. The intraneural edema, demyelination, and Wallerian degeneration of all 17 rats were scored pathologically. RESULTS: The pathology scores of the rats in the TNF-alpha inhibitor treatment group (1.38 +/- 0.74) indicated a mild degree of intraneural edema compared to the saline treatment group (2.25 +/- 0.50, p = 0.041). In addition, rats in the TNF-alpha inhibitor treatment group (2.13 +/- 0.35) had a mild degree of demyelination compared to the saline treatment group (2.75 +/- 0.50, p = 0.038) and the triamcinolone treatment group (2.80 +/- 0.45, p = 0.019). The differences in the pathology scores for Wallerian degeneration were not statistically significant in all three study groups (p = 0.658). CONCLUSION: The epidural injection of a TNF-alpha inhibitor was more effective than a placebo and comparable to triamcinolone in reducing pathological nerve injury progression

Keywords : administration & dosage,Adult,analysis,Animals,antagonists & inhibitors,Antibodies,Antibodies,Monoclonal,Chronic Disease,complications,Demyelinating Diseases,Disease Models,Animal,Disease Progression,drug effects,drug therapy,Edema,etiology,Ganglia,Spinal,Infliximab,Injections,Epidural,injuries,Male,methods,Nerve Compression Syndromes,pathology,prevention & control,Radiculopathy,Radiology,Rats,Rats,Inbred F344,Triamcinolone,Tumor Necrosis Factor-alpha,Wallerian Degeneration,, Epidural,Tnf?,Inhibitor,Injection, fibromyalgia trigger points massage

Date of Publication : 2012 May

Authors : Kim NR;Lee JW;Jun SR;Lee IJ;Lim SD;Yeom JS;Koo KH;Jin W;Kang HS;

Organisation : Department of Radiology, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam, Gyeongi-do 463-707, South Korea

Journal of Publication : Skeletal Radiol

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21713551

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