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Effects of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion – Lumbar Fusion

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The article explores the impact of anti-osteoporosis treatment on elderly patients with osteoporosis undergoing lumbar discectomy and fusion (LIF) for lumbar degenerative diseases. The study conducted from January to December 2022 included 165 patients divided into three groups based on bone density. The results indicated that perioperative anti-osteoporosis treatment in elderly patients with LIF and osteoporosis could reduce bone resorption, enhance fusion, and improve short-term outcomes in terms of radiological and functional aspects. Anti-osteoporosis therapy was found to have a positive effect on the concentration of various serum markers and the degree of fusion in the different groups. This study highlights the importance of anti-osteoporosis medication in improving outcomes for elderly patients undergoing lumbar fusion procedures

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

: In elderly patients with LIF and osteoporosis, anti-osteoporosis therapy could reduce bone resorption and thus facilitate fusion. Anti-osteoporosis medication tends to enhance radiological, functional, and fusion short-term outcomes.

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J Back Musculoskelet Rehabil. 2024 Mar 20. doi: 10.3233/BMR-230381. Online ahead of print. ABSTRACT BACKGROUND: The effect of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion (LIF) for lumbar degenerative diseases is not well known. OBJECTIVE: This study aimed to evaluate the effect of perioperative anti-osteoporosis treatment in the patients with,

J Back Musculoskelet Rehabil. 2024 Mar 20. doi: 10.3233/BMR-230381. Online ahead of print.

ABSTRACT

BACKGROUND: The effect of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion (LIF) for lumbar degenerative diseases is not well known.

OBJECTIVE: This study aimed to evaluate the effect of perioperative anti-osteoporosis treatment in the patients with osteoporosis and LIF.

METHODS: From January to December 2022, patients were divided into three groups according to the inclusive criteria: the normal group (Group A), the osteopenia group (Group B) and the osteoporosis group (Group C). Quantitative computed tomography (QCT), height of the intervertebral space (HIS), segmental sagittal angle (SSA), visual analogue scale (VAS) score and Oswestry Disability Index (ODI) were compared between the groups at the follow-up time. The serum Ca2 + , osteocalcin (OC), propeptide of type I procollagen (PINP) C-terminal cross-linking telopeptide of type I collagen (β-CTX) and 25-OH vitamin D (25-OH VD) levels were compared between the groups at the time of follow-up. Interbody fusion was graded on the X-ray and CT images at the follow-up time.

RESULTS: There were 165 patients in this study. There were significant differences in the mean age, mean score, HIS and SSA between the groups at the different follow-up times. There were significant differences in the concentrations of serum Ca2 + , OC, β-CTX, 25-OH VD and PINP at the sixth month after surgery between the groups. There were significant differences in the concentrations of serum Ca2 + , β-CTX and 25-OH VD between the pre-surgery and at six months after surgery in Group B and β-CTX and 25-OH VD in Group C. There was a significant difference in the degree of fusion between Group B and C (χ2= 5.6243, P< 0.05).

: In elderly patients with LIF and osteoporosis, anti-osteoporosis therapy could reduce bone resorption and thus facilitate fusion. Anti-osteoporosis medication tends to enhance radiological, functional, and fusion short-term outcomes.

PMID:38607748 | DOI:10.3233/BMR-230381

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Effects of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion

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J Back Musculoskelet Rehabil. 2024 Mar 20. doi: 10.3233/BMR-230381. Online ahead of print. ABSTRACT BACKGROUND: The effect of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion (LIF) for lumbar degenerative diseases is not well known. OBJECTIVE: This study aimed to evaluate the effect of perioperative anti-osteoporosis treatment in the patients with

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