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Effectiveness of vancomycin powder for preventing postoperative spinal infection – Lumbar Fusion

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The article assessed the effectiveness of Vancomycin Powder (VP) in preventing post-surgical infections (PSI) and the occurrence of resistant organisms after four years of routine use. The study included 1063 patients who underwent spinal fusion surgeries between 2010 and 2020. The results showed that the rate of PSI was not significantly different between the group that used VP and the non-VP group. Additionally, the occurrence of resistant organisms and critical complications related to VP were minimal. The study concluded that the use of intrawound VP may not impact PSI or the occurrence of resistant organisms and can be considered a safe option for preventing infections in spinal fusion surgeries

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most specialised treatment hospital on Harley Street UK

Published article

S: The use of intrawound VP may not affect the PSI and occurrence of resistant organism and may not cause critical complications. Therefore, clinicians may decide whether to use VP for preventing PSI not worrying about its safety.

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Clin Neurol Neurosurg. 2024 Mar 2;239:108222. doi: 10.1016/j.clineuro.2024.108222. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to assess the effectiveness of Vancomycin Power (VP) and the occurrence of resistant organisms after four-year of routine VP use.METHODS: The study included 1063 patients who underwent posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) between January,

Clin Neurol Neurosurg. 2024 Mar 2;239:108222. doi: 10.1016/j.clineuro.2024.108222. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aimed to assess the effectiveness of Vancomycin Power (VP) and the occurrence of resistant organisms after four-year of routine VP use.

METHODS: The study included 1063 patients who underwent posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) between January 2010 and February 2020. Intrawound VP was applied to all instrumented fusions starting in January 2016. The patients were divided into two groups: those who did not apply VP (non-VP) (n = 605) between 2010 and 2015, and those who did apply VP (VP) (n = 458) between 2016 and 2020. The baseline characteristics, clinical symptoms, infection rate, and causative organisms were compared between the two groups.

RESULTS: The rate of PSI was not significantly different between the non-VP group (1.32 %, n = 8) and the VP group (1.09 %, n = 5). Although adjusted by diabetes mellitus, VP still did not show statistical significance (OR = 0.757 (0.245-2.345), p = 0.630). There were no critical complications that were supposed to relation with vancomycin powder. In the 13 cases of PSI, seven pathogens were isolated, with a gram-negative organism identified in the non-VP group. However, the type of organism was not significantly different between the two groups.

S: The use of intrawound VP may not affect the PSI and occurrence of resistant organism and may not cause critical complications. Therefore, clinicians may decide whether to use VP for preventing PSI not worrying about its safety.

PMID:38484602 | DOI:10.1016/j.clineuro.2024.108222

The London Spine Unit : most specialised treatment hospital on Harley Street UK

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Effectiveness of vancomycin powder for preventing postoperative spinal infection

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Clin Neurol Neurosurg. 2024 Mar 2;239:108222. doi: 10.1016/j.clineuro.2024.108222. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to assess the effectiveness of Vancomycin Power (VP) and the occurrence of resistant organisms after four-year of routine VP use.METHODS: The study included 1063 patients who underwent posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) between January

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