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Effect Of Patient-Specific Factors On Regeneration In Lumbar Spine At Healthy Disc And Total Disc Replacement. Computer Simulation – Lumbar Disc Replacement

The article discusses the impact of degenerative diseases of the spine on patient quality of life and presents the results of numerical modelling of the mechanical behavior of the lumbar spine with patient-specific conditions under physiological loads. The study examines the influence of degenerative changes in the spine and the presence of an endoprosthesis on tissue regeneration. The results show that total disc replacement may lead to osseointegration of artificial disc plates in healthy bone tissue, but could result in bone resorption and increased risk of neoplastic processes in osteoporotic bone tissue. Dynamic loads may help improve osseointegration in pathological conditions. Overall, the study emphasizes the importance of considering biomechanical and mechanobiological principles in designing interventions for spinal degenerative diseases

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : best situated sugical centre in UK

Published article

CONCLUSIONS: The results obtained in the case of healthy spine and osteoporotic bone tissues correspond to the experimental data on biomechanics and possible methods of IVD regeneration from the position of mechanobiological principles. The results obtained with an artificial disc (with keel-type fixation) showed that the use of this type of endoprosthesis in healthy bone tissues allows to reproduce the function of the natural intervertebral disc and does not contribute to the development of…

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Abstract Background and objective: Degenerative diseases of the spine have a negative impact on the quality of life of patients. This study presents the results of numerical modelling of the mechanical behaviour of the lumbar spine with patient-specific conditions at physiological loads. This paper aims to numerically study the influence of degenerative changes in the,

Abstract

Background and objective: Degenerative diseases of the spine have a negative impact on the quality of life of patients. This study presents the results of numerical modelling of the mechanical behaviour of the lumbar spine with patient-specific conditions at physiological loads. This paper aims to numerically study the influence of degenerative changes in the spine and the presence of an endoprosthesis on the creation of conditions for tissue regeneration.

Methods: A numerical model of the mechanical behaviour of lumbar spine at healthy and after total disc replacement under low-energy impacts equivalent to physiological loads is presented. The model is based on the movable cellular automaton method (discrete elements), where the mechanical behaviour of bone tissue is described using the Biot poroelasticity accounting for the presence and transfer of interstitial biological fluid. The nutritional pathways of the intervertebral disc in cases of healthy and osteoporotic bone tissues were predicted based on the analysis of the simulation results according to the mechanobiological principles.

Results: Simulation of total disc replacement showed that osseointegration of the artificial disc plates occurs only in healthy bone tissue. With total disc replacement in a patient with osteoporosis, there is an area of increased risk of bone resorption in the near-contact area, approximately 1 mm wide, around the fixators. Dynamic loads may improve the osseointegration of the implant in pathological conditions of the bone tissue.

Conclusions: The results obtained in the case of healthy spine and osteoporotic bone tissues correspond to the experimental data on biomechanics and possible methods of IVD regeneration from the position of mechanobiological principles. The results obtained with an artificial disc (with keel-type fixation) showed that the use of this type of endoprosthesis in healthy bone tissues allows to reproduce the function of the natural intervertebral disc and does not contribute to the development of neoplastic processes. In the case of an artificial disc with osteoporosis of bone tissues, there is a zone with increased risk of tissue resorption and development of neoplastic processes in the area near the contact of the implant attachment. This circumstance can be compensated by increasing the loading level.

Keywords: Cancer; Computer simulation; Lumbar spine; Method of movable cellular automata; Poroelasticity; Total disc replacement.

The London Spine Unit : best situated sugical centre in UK

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Effect of patient-specific factors on regeneration in lumbar spine at healthy disc and total disc replacement. Computer simulation

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Abstract Background and objective: Degenerative diseases of the spine have a negative impact on the quality of life of patients. This study presents the results of numerical modelling of the mechanical behaviour of the lumbar spine with patient-specific conditions at physiological loads. This paper aims to numerically study the influence of degenerative changes in the

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