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Dosimetric comparability of head and neck most cancers sufferers deliberate with multivendor volumetric modulated arc remedy expertise.

J Most cancers Res Ther. 2017 Jan-Mar;13(1):122-130

Authors: Kathirvel M, Subramani V, Subramanian VS, Swamy ST, Arun G, Kala S

Summary
AIM: Function of this examine is to dosimetrically evaluate head and neck (H and N) most cancers sufferers deliberate with multivendor volumetric modulated arc remedy (VMAT) expertise. VMAT remedy planning may be performed utilizing organic (remedy planning system [TPSB]: Monaco) or bodily (TPSP: Eclipse)-based value perform optimization methods. Planning and dosimetric comparisons had been performed in each methods for H and N instances.
MATERIALS AND METHODS: Twenty H and N sufferers had been retrospectively chosen for this examine. VMAT plans had been generated utilizing TPSP (V11.zero) and TPSB (V3.zero) TPS. A complete dose of 66 Gy (planning goal quantity 1 [PTV1]) and 60 Gy (PTV2) had been prescribed to main and nodal goal volumes. Scientific planning targets had been achieved by each the optimization methods. Dosimetric parameters had been calculated for PTVs, and quantitative analyses had been carried out for important organs. Monitor items had been in contrast between two TPSs, and gamma evaluation was carried out between I’matriXX measured and TPS calculated.
RESULTS: Clinically, acceptable VMAT plans confirmed comparable dose distributions between TPSB and TPSP optimization methods. Comparability of imply dose, homogeneity index, and conformity index for PTV1 confirmed no statistical distinction (P – zero.922, zero.096, and zero.097); nonetheless, in PTV2 statistically important distinction was noticed (P – zero.024, zero.008, and zero.002) between TPSB and TPSP. TPSB optimization confirmed statistically important superiority for spinal twine and brainstem (D1% P – zero.0078, zero.00002) whereas improved parotid sparing was noticed in TPSP optimization (imply dose P – zero.00205). Gamma evaluation illustrated that each programs may produce clinically deliverable plans.
CONCLUSION: VMAT plans by TPSP and TPSB supplied clinically acceptable dose distributions. TPSB-based optimization confirmed enhanced sparing of serial organs whereas TPSP-based optimization confirmed superior sparing of parallel organs.

PMID: 28508845 [PubMed – indexed for MEDLINE]