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Does insulin-like growth factor 1 receptor (IGF-1R) targeting provide new treatment options for chordomas? A retrospective clinical and immunohistochemical study

AIMS: The overall prognosis of chordoma is poor, and current treatment options are limited. The insulin-like growth factor 1 receptor (IGF-1R) pathway is important for cell signalling, and attractive for selective inhibition. We investigated the expression of IGF-1R and its ligands, IGF-1 and IGF-2, in a series of 50 chordomas, in order to assess whether IGF-1R-signalling could be a potential target for specific inhibition in chordomas. METHODS AND RESULTS: Fifty chordomas (34 primary tumours, 16 recurrences) from 44 patients were evaluated immunohistochemically for the expression of IGF-1R, IGF-1 and IGF-2. Thirty-eight chordomas (76%) expressed IGF-1R, 46 (92%) expressed IGF-1 and 25 (50%) expressed IGF-2. Semi-quantitative analyses revealed a moderate to strong staining intensity in >/= 50% of tumour cells for IGF-1R, IGF-1 and IGF-2 in 18 (36%), 32 (64%) and eight (16%) chordomas, respectively. Tumour volume correlated significantly with IGF-1R-staining intensity in primary chordomas (P = 0.042). CONCLUSIONS: IGF-1R and IGF-1 are expressed in the majority of chordomas. IGF-1 expression is much stronger than IGF-2 expression. Patients whose chordomas show a moderate to strong staining intensity in >/= 50% of tumour cells for IGF-1R (36%) might benefit most from IGF-1R targeting, particularly if they suffer from large and surgically non-resectable chordomas

Keywords : Adult,Age Factors,Aged,Aged,80 and over,Austria,Biomarkers,Biomarkers,Tumor,Chordoma,diagnosis,epidemiology,Female,Germany,Growth,Humans,Insulin-Like Growth Factor I,Insulin-Like Growth Factor II,Ligands,Male,metabolism,methods,Middle Aged,Molecular Targeted Therapy,mortality,Neoplasm Recurrence,Local,Patients,Prognosis,Receptor,IGF Type 1,Recurrence,Retrospective Studies,Spinal Neoplasms,surgery,Survival Rate,Universities,Young Adult,, Insulinlike,Growth,Factor1,Receptor, piriformis syndrome pain relief

Date of Publication : 2012 May

Authors : Scheipl S;Froehlich EV;Leithner A;Beham A;Quehenberger F;Mokry M;Stammberger H;Varga PP;Lazary A;Windhager R;Gattenloehner S;Liegl B;

Organisation : Department of Orthopaedics and Orthopaedic Surgery, Medical University of Graz, Graz, Austria

Journal of Publication : Histopathology

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/22372631

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