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Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis – Lumbar Fusion

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The article investigated the presence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC). A cross-sectional sub-analysis of a prospective cohort found significant differences in blood biomarkers in MC patients, including elevated levels of CCL5 and lower levels of MIF. Patients with MC also showed higher levels of disc degeneration and displacement severity. The study suggests that CCL5 and MIF may be independently associated with MC patients, regardless of disc alterations. This study is the first to identify specific circulating blood biomarkers associated with symptomatic patients with lumbar MC

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
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Published article

: This “proof-of-concept” study is the first to identify specific and significantly circulating blood biomarkers associated with symptomatic patients with lumbar MC, independent of disc alterations of degeneration and/or bulges/herniations. Specifically, differences in CCL5 and MIF protein levels were significantly noted in MC patients compared to those without MC.

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Eur Spine J. 2024 Mar 7. doi: 10.1007/s00586-024-08192-y. Online ahead of print.ABSTRACTPURPOSE: The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC).METHODS: A cross-sectional sub-analyses of a prospective cohort was performed. Fasting blood samples were collected from patients with and without lumbar MC who,

Eur Spine J. 2024 Mar 7. doi: 10.1007/s00586-024-08192-y. Online ahead of print.

ABSTRACT

PURPOSE: The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC).

METHODS: A cross-sectional sub-analyses of a prospective cohort was performed. Fasting blood samples were collected from patients with and without lumbar MC who had undergone spinal fusion or microdiscectomy. An 80-plex panel and CCL5/RANTES were used to assess preoperative plasma cytokine concentrations. Patient demographics and imaging phenotypes were also assessed.

RESULTS: Thirty-one subjects were analysed (n = 18 no MC; n = 13 MC). No significant differences were found in age, sex, body mass index, smoking and alcohol history, and surgical procedure (i.e. fusion, decompression) between the two groups (p > 0.05). Several statistically significant blood biomarkers in MC patients were identified, including elevated levels of C-C Motif Chemokine Ligand 5 (CCL5, p = 0.0006), while Macrophage Migration Inhibitory Factor (MIF) was significantly lower (p = 0.009). Additionally, C-X-C Motif Chemokine Ligand 5 (CXCL5, p = 0.052), Pentraxin 3 (PTX3, p = 0.06) and Galectin-3 (Gal-3, p = 0.07) showed potential relevance. Moreover, MC patients exhibited significantly higher levels of disc degeneration (p = 0.0001) and displacement severity (p = 0.020). Based on multivariate analyses and controlling for disc degeneration/displacement, CCL5 (OR 1.02; 95% CI 1.002-1.033; p = 0.028) and MIF (OR 0.60; 95% CI 0.382-0.951; p = 0.030) were independently associated with MC patients.

: This “proof-of-concept” study is the first to identify specific and significantly circulating blood biomarkers associated with symptomatic patients with lumbar MC, independent of disc alterations of degeneration and/or bulges/herniations. Specifically, differences in CCL5 and MIF protein levels were significantly noted in MC patients compared to those without MC.

PMID:38451373 | DOI:10.1007/s00586-024-08192-y

The London Spine Unit : most experienced spine clinic on Harley Street UK

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Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis

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Eur Spine J. 2024 Mar 7. doi: 10.1007/s00586-024-08192-y. Online ahead of print.ABSTRACTPURPOSE: The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC).METHODS: A cross-sectional sub-analyses of a prospective cohort was performed. Fasting blood samples were collected from patients with and without lumbar MC who

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