Diffusion-weighted MRI of pulmonary lesions: Comparability of obvious diffusion coefficient and lesion-to-spinal wire sign depth ratio in lesion characterization.
J Magn Reson Imaging. 2017 Mar;45(Three):845-854
Authors: Çakmak V, Ufuk F, Karabulut N
PURPOSE: To judge the diagnostic efficiency of minimal obvious diffusion coefficient (ADCmin ) and lesion-to-spinal wire sign depth ratio (LSR) within the differentiation of benign and malignant pulmonary lesions.
MATERIALS AND METHODS: Forty-seven sufferers (36 males, 11 ladies; vary, 17-81 years) with 62 pulmonary lesions underwent magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) carried out utilizing a 1.5T scanner throughout free-breathing utilizing b 600 s/mm2 . The ADCmin values and LSR had been calculated. A receiver working attribute (ROC) curve evaluation was carried out to detect the edge worth of the ADCmin and LSR values for discrimination between benign and malignant pulmonary lesions.
RESULTS: There have been 42 malignant (33 major tumors, 9 metastases) and 20 benign lesions. The imply ADCmin ?±?commonplace deviations (×10-Three mm2 /s) had been 1.45?±?Zero.33 for malignant tumors, and a couple of.four?±?Zero.69 for benign lesions (P < Zero.001). The imply LSR?±?commonplace deviations for lung most cancers was 1.24?±?Zero.78, and for benign lesions was Zero.55?±?Zero.57 (P < Zero.001). The world underneath the ROC curve for ADCmin (Zero.931; 95% confidence interval [CI]: Zero.868-Zero.993) was higher than that for LSR (Zero.801; 95% CI: Zero.675-Zero.926) (P?=?Zero.029). For benign/malignant discrimination, the ROC curve confirmed threshold worth of ADCmin to be 1.78 × 10-Three mm2 /s and that of LSR to be Zero.86. Utilizing these cutoff values, accuracy of ADCmin and LSR had been 89%, 74%, respectively (P?=?Zero.383).
CONCLUSION: Being a contrast-free and radiation-free method, DWI permits discrimination of benign and malignant lung lesions. The ADCmin worth carried out marginally higher than LSR values in distinction of benign and malignant lesions.
LEVEL OF EVIDENCE: 1 J. Magn. Reson. Imaging 2017;45:845-854.
PMID: 27519160 [PubMed – indexed for MEDLINE]