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Diagnostic And Prognostic Significance Of MiR-486-5p In Patients Who Underwent Minimally Invasive Surgery For Lumbar Spinal Stenosis London Spine Lumbar Stenosis

The article investigates the expression and clinical value of microRNA miR-486-5p in diagnosing lumbar spinal stenosis (LSS) patients and predicting clinical outcomes after minimally invasive spinal surgery (MISS) in LSS patients. The study included 52 LSS patients, 46 patients with lumbar intervertebral disk herniation (LDH), and 42 healthy controls. Results show that serum miR-486-5p was upregulated in LSS patients and had high diagnostic value for screening LSS patients. Additionally, the miRNA could predict the 6-month clinical outcomes after MISS therapy and was positively correlated with inflammatory factors IL-1β and TNF-α in LSS patients. The findings suggest that miR-486-5p could serve as an indicator for diagnosing LSS and predicting clinical outcomes after MISS therapy, potentially by regulating inflammatory responses

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most specialised spinal hospital in London

Published article

miR-486-5p, increased in LSS patients, can function as an indicator to diagnose LSS and a predictive indicator for the clinical outcomes after MISS therapy in LSS patients. In addition, miR-486-5p may regulate LSS progression by modulating inflammatory responses.

Spine Lumbar Spinal Stenosis Expert. Best Spinal Surgeon UK
Abstract Background: This study aimed to investigate the expression and clinical value of microRNA miR-486-5p in diagnosing lumbar spinal stenosis (LSS) patients and predicting the clinical outcomes after minimally invasive spinal surgery (MISS) in LSS patients, and the correlation of miR-486-5p with inflammatory responses in LSS patients. Methods: This study included 52 LSS patients, 46,

Abstract

Background: This study aimed to investigate the expression and clinical value of microRNA miR-486-5p in diagnosing lumbar spinal stenosis (LSS) patients and predicting the clinical outcomes after minimally invasive spinal surgery (MISS) in LSS patients, and the correlation of miR-486-5p with inflammatory responses in LSS patients.

Methods: This study included 52 LSS patients, 46 patients with lumbar intervertebral disk herniation (LDH) and 42 healthy controls. Reverse transcription quantitative PCR was used to detect miR-486-5p expression. The ability of miR-486-5p to discriminate between different groups was evaluated by receiver-operating characteristic analysis. The visual analogue scale (VAS), Oswestry Disability Index (ODI) and Japanese Orthopaedic Association (JOA) scores at 6 months postoperatively were used to reflect the clinical outcomes of LSS patients. Enzyme-linked immunosorbent assay was used to measure the levels of inflammatory factor [interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)]. The correlation of miR-486-5p with continuous variables in LSS patients was evaluated by the Pearson correlation coefficient.

Results: Expression of serum miR-486-5p was upregulated in LSS patients and had high diagnostic value to screen LSS patients. In addition, serum miR-486-5p could predict the 6-month clinical outcomes after MISS therapy in LSS patients. Moreover, serum miR-486-5p was found to be positively correlated with the levels of IL-1β and TNF-α in patients with LSS.

miR-486-5p, increased in LSS patients, can function as an indicator to diagnose LSS and a predictive indicator for the clinical outcomes after MISS therapy in LSS patients. In addition, miR-486-5p may regulate LSS progression by modulating inflammatory responses.

Keywords: Clinical outcomes; Diagnosis; Inflammation; Lumbar spinal stenosis; Minimally invasive spinal surgery; miR-486-5p.

The London Spine Unit : most specialised spinal hospital in London

Read the original publication:

Diagnostic and prognostic significance of miR-486-5p in patients who underwent minimally invasive surgery for lumbar spinal stenosis

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Abstract Background: This study aimed to investigate the expression and clinical value of microRNA miR-486-5p in diagnosing lumbar spinal stenosis (LSS) patients and predicting the clinical outcomes after minimally invasive spinal surgery (MISS) in LSS patients, and the correlation of miR-486-5p with inflammatory responses in LSS patients. Methods: This study included 52 LSS patients, 46

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