Prognosis and therapy patterns for sufferers with leptomeningeal metastasis from stable tumors throughout Europe.
J Neurooncol. 2017 Jun;133(2):419-427
Authors: Le Rhun E, Rudà R, Devos P, Hoang-Xuan Okay, Brandsma D, Pérez Segura P, Soffietti R, Weller M
Leptomeningeal metastases are a late manifestation of systemic most cancers which impacts as much as 10% of sufferers with stable tumors. Prognosis is poor, and total survival at 1 yr is just roughly 10%. Administration relies upon primarily on normal and neurological situation, major tumor, and patterns of metastasis, notably absence or presence of concurrent systemic or stable mind metastases. Right here we got down to characterize present follow patterns of prognosis and therapy of sufferers with leptomeningeal metastasis in Europe. We ready a web-based survey together with 25 easy or a number of decisions questions on greatest follow supplemented by eight case vignettes with varied prognosis and administration choices. The survey was despatched to the membership of the European Affiliation of Neuro-Oncology and the European Organisation for Analysis and Therapy of Most cancers Mind Tumor Group. Between April 7, 2016 and August eight, 2016, 224 colleagues from 26 nations initiated the survey, 115 colleagues accomplished the entire survey. There have been main variations each within the normal diagnostic and therapeutic method, e.g., concerning the usage of cerebrospinal fluid (CSF) circulate research, intra-CSF chemotherapy, varied forms of radiotherapy, and much more so when deciding on selections on diagnostic and therapeutic measures for single case vignettes. Prognosis and therapy selections for sufferers with leptomeningeal metastasis from stable tumors differ broadly throughout Europe. Standardization of prognosis and analysis instruments in addition to managed research to enhance the extent of proof for all therapeutic approaches to LM are required.
PMID: 28455788 [PubMed – indexed for MEDLINE]