Deep hyperthermia with the HYPERcollar system mixed with irradiation for superior head and neck carcinoma – a feasibility examine.
Int J Hyperthermia. 2018 Could 11;:1-Eight
Authors: Verduijn GM, de Wee EM, Rijnen Z, Togni P, Hardillo JAU, Ten Hove I, Franckena M, van Rhoon GC, Paulides MM
PURPOSE: Radiotherapy (RT) remedy of locally-advanced and recurrent head and neck carcinoma (HNC) ends in disappointing outcomes. Mixture of RT with cisplatin or cetuximab improves survival however the elevated toxicity and affected person’s comorbidity warrant the necessity for a less-toxic radiosensitizer. Stimulated by a number of randomized research demonstrating the radio-sensitizing impact of hyperthermia, we developed the HYPERcollar. Right here, we report early expertise and toxicity in sufferers with superior HNC.
METHODS AND MATERIALS: 119 hyperthermia therapies given to 27 sufferers had been analyzed. Hyperthermia was utilized as soon as per week by the HYPERcollar aimed toward reaching 39-43?°C within the goal space, as much as sufferers’ tolerance. Pre-treatment planning was used to optimize remedy settings. When attainable, invasive thermometry catheters had been positioned.
RESULTS: Imply energy utilized throughout the 119 hyperthermia therapies ranged from 120 to 1007?W (median 543?W). 15 (13%) hyperthermia therapies weren’t totally accomplished as a consequence of: ache allotted to hyperthermia (6/15), dyspnea from sticky saliva related to irradiation (2/15) and unknown causes (7/15). No extreme problems or enhanced thermal or mucosal toxicities had been noticed. Excluding post-operative remedy, response charges after three?months had been 46% (full) and seven% (partial).
CONCLUSION: Hyperthermia with the HYPERcollar proved to be protected and possible with good compliance and promising end result.
PMID: 29747544 [PubMed – as supplied by publisher]