Correlation between MBL2/CD14/TNF-? gene polymorphisms and susceptibility to spinal tuberculosis in Chinese language inhabitants.
Biosci Rep. 2018 02 28;38(1):
Authors: Zheng M, Shi S, Wei W, Zheng Q, Wang Y, Ying X, Lu D
OBJECTIVE: The current research investigated the scientific significance of mannose-binding lectin 2 (MBL2), cluster of differentiation 14 (CD14) and tumour necrosis factor-? (TNF-?) gene polymorphisms in sufferers with spinal tuberculosis (TB) in Chinese language inhabitants.
METHODS: A complete of 240 sufferers with spinal TB have been enrolled within the current research from Could 2013 to August 2016 at Hangzhou Crimson Cross Hospital. A complete of 150 age- and sex-matched wholesome topics have been enrolled as controls. The genomic DNA was extracted from the peripheral blood of all topics, and the MBL2, CD14 and TNF-? gene polymorphisms have been detected by direct DNA sequencing.
RESULTS: (1) In contrast with controls, sufferers with spinal TB exhibited a considerably increased frequency of the XY genotype on the -221G>C polymorphism in addition to the Q allele and PQ genotype or an affiliation with the QQ genotype on the +4C>T polymorphism within the MBL2 gene. (2) In contrast with controls, sufferers with spinal TB exhibited a considerably increased frequency of the T allele and TT genotype or an affiliation with the CT genotype on the -159C>T polymorphism within the CD14 gene. (three) In contrast with controls, sufferers with spinal TB exhibited a considerably increased frequency of the T allele and the CT genotype or an affiliation with the TT genotype on the TNF-857 polymorphism within the TNF-? gene.
CONCLUSION: The -221G>C polymorphism of MBL2, the -159C>T polymorphism of CD14 and the TNF-857 polymorphism of TNF-? are threat components for spinal TB and could also be concerned within the improvement of spinal TB within the Chinese language inhabitants. These components are indicators of susceptibility to spinal TB and require scientific consideration.
PMID: 29298876 [PubMed – indexed for MEDLINE]