Comparability of trabecular bone rating and hip structural evaluation with FRAX® in postmenopausal girls with sort 2 diabetes mellitus.
Getting older Clin Exp Res. 2017 Oct;29(5):951-957
Authors: Bonaccorsi G, Fila E, Messina C, Maietti E, Ulivieri FM, Caudarella R, Greco P, Guglielmi G
PURPOSE: To judge (a) the efficiency in predicting the presence of bone fractures of trabecular bone rating (TBS) and hip structural evaluation (HSA) in sort 2 diabetic postmenopausal girls in comparison with a management group and (b) the fracture prediction capability of TBS versus Fracture Threat Calculator (FRAX®) in addition to whether or not TBS can enhance the fracture prediction capability of FRAX® in diabetic girls.
METHODS: Eighty diabetic postmenopausal girls had been matched with 88 controls with out main ailments for age and physique mass index. The person 10-year fracture danger was assessed by FRAX® software for Europe-Italy; bone mineral density (BMD) at lumbar backbone, femoral neck and whole hip was evaluated via dual-energy X-ray absorptiometry; TBS measurements had been taken utilizing the identical area of curiosity because the BMD measurements; HSA was carried out at proximal femur with the HSA software program.
RESULTS: Concerning variables of curiosity, the one vital distinction between diabetic and management teams was noticed for the worth of TBS (median worth: 1.215; IQR 1.138-1.285 in controls vs. 1.173; IQR 1.082-1.217 in diabetic; p = zero.002). The prevalence of fractures in diabetic girls was nearly tripled than in controls (13.eight vs. three.four %; p = zero.02). The receiver operator attribute curve evaluation confirmed that TBS alone (AUC = zero.71) had no considerably decrease discriminative energy for fracture prediction in diabetic girls than FRAX main adjusted for TBS (AUC = zero.74; p = zero.65).
CONCLUSION: In diabetic postmenopausal girls TBS is a superb software in figuring out fragility fractures.
PMID: 27722900 [PubMed – indexed for MEDLINE]