19 Harley St, London, W1G 9QJ, UK

Comparative Evaluation Of The Sedative And Analgesic Effects Of Caudal Epidural Administration Of Lidocaine Alone Or In Combination With Xylazine, Detomidine, Medetomidine, And Dexmedetomidine In Mediterranean Miniature Donkeys London Spine

The London Spine Unit : best recognised day surgery hospital on Harley Street UK

Published article<

The present study aimed to compare the sedative and analgesic effects of caudal epidural administration of lidocaine alone or in combination with four different α(2)-adrenergic agonists in Mediterranean miniature donkeys. A total of ten clinically healthy (five males and five females) Mediterranean miniature donkeys with an age of 5 ± 1 years, a weight of 100 ± 2 kg and a height at the withers of 0.8 ± 0.06 m (mean ± standard deviation) were used in experimental, crossover (Latin square),…
Lumbar Disc Replacement Expert. Best Spinal Surgeon UK

Abstract

The present study aimed to compare the sedative and analgesic effects of caudal epidural administration of lidocaine alone or in combination with four different α2-adrenergic agonists in Mediterranean miniature donkeys. A total of ten clinically healthy (five males and five females) Mediterranean miniature donkeys with an age of 5 ± 1 years, a weight of 100 ± 2 kg and a height at the withers of 0.8 ± 0.06 m (mean ± standard deviation) were used in experimental, crossover (Latin square), randomized, and blinded study. Animals were assigned to five treatment groups including lidocaine alone (0.22 mg kg-1), or associated with one among xylazine (0.17 mg kg-1), detomidine (30 μg kg-1), medetomidine (15 μg kg-1), dexmedetomidine (5 μg kg-1) with a minimum washout period of 8 days between treatments. The degree of sedation was investigated using a simple descriptive scale of 0-3. Sedation scores were compared at each time using nonparametric (Kruskal-Wallis and Mann-Whitney U) tests. Analgesia was assessed by pinprick test. Sedation was greater in lidocaine and/or α2-adrenergic agonist groups than in lidocaine group at 45-75 minutes after drug administration (P < .05). There were no significant differences among groups in time to onset of analgesia and ataxia and also in number of animals with complete perineal analgesia and ataxia. Duration of analgesia and ataxia were longer in lidocaine and/or α2-adrenergic agonist groups than in lidocaine (P < .05). There were no significant differences among lidocaine and/or α2-adrenergic agonist groups in sedation score and duration of analgesia and ataxia. No significant differences were observed in heart and respiratory rate and also rectal temperature at any time points between groups and within groups. Caudal epidural administration of α2– adrenergic agonists associated with lidocaine resulted in sedative effects on Mediterranean miniature donkeys, while lidocaine alone did not induce sedation. These drugs associations should be considered when superior analgesia is advocated.

Keywords: Antinociception; Lidocaine, Miniature donkeys; Sedation; α(2)-adrenergic agonists.

The London Spine Unit : best recognised day surgery hospital on Harley Street UK

Read the original publication from Pubmed:

Comparative Evaluation of the Sedative and Analgesic Effects of Caudal Epidural Administration of Lidocaine Alone or in Combination With Xylazine, Detomidine, Medetomidine, and Dexmedetomidine in Mediterranean Miniature Donkeys

Doctors Specialising in Cervical Epidural Injection
Mr Mo Akmal MD
Mr Mo Akmal, MD, stands as a innovator in the ...
Mr Purnajyoti Banerjee
Mr. Purnajyoti Banerjee is a consultant in the field of ...

Related Posts

0/5 (0 Reviews)

Trusindex Reviews

London Spine Unit Harley Street Hospital

A Focus on High Quality Specialised Care

We are a specialist Private Hospital based on Harley Street, London UK The Harley Street Hospital, Day Surgery Hospital

We provide exclusive health services for individuals seeking Advanced medical, non-surgical or minimally invasive treatments. We are covered by All Insurance Companies apart from AXA PPP

Our Medical Director and Lead Spinal Surgeon Mr Mo Akmal MD is a world renowned Spine Specialist Consultant with over 20 years of experience. He and his team have developed revolutionary techniques to perform all types of Spinal Surgery as a Day Case procedure without traditional General Anaesthetic.

We are constantly improving our techniques for treatment and improving facilities for our patients.

Book your Appointment Now 
Check out our Reviews 
Check out our Patient Videos 
Check our Mr Akmal’s Profile

 

What our patients say ...

Abstract The present study aimed to compare the sedative and analgesic effects of caudal epidural administration of lidocaine alone or in combination with four different α2-adrenergic agonists in Mediterranean miniature donkeys. A total of ten clinically healthy (five males and five females) Mediterranean miniature donkeys with an age of 5 ± 1 years, a weight…

Revolutionary Keyhole surgical technique to vaporise bulging discs

Dr Mo Akmal Medical Director
Dr Mo Akmal MD - Lead Spinal Surgeon

Laser Disc Surgery can be performed under local anaesthetic at The Harley Street Hospital.

Initial Consultation

with Consultant Spine Surgeon
£ 250
  • No Waiting Times
  • Top NHS affiliated Consultant
  • Includes Clinical Review and Report
  • Multidisciplinary discussion
  • Review of Previous Scans and Reports

Follow up Consultation

any appointment after initial consultation
£ 180
  • Top NHS affiliated Consultant
  • Includes Clinical Review and Report
  • Multidisciplinary discussion

High Resolution MRI Scan

any Single Region (3.0 Tesla)
£ 600
  • No waiting times
  • Includes Full Radiologist Report
  • Open or Closed MRI scan types
  • Copy of Scan on CD

Website Offer

Pre-Booked Online
£1130
£ 800
  • Initial Consultation
  • MRI Scan (Single Region)
  • Follow Up consultation
  • Same Day One Stop Visit
  • Full Medical and MRI scan Report
  • Copy of scan on CD
Popular

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810