Collagen IX gene polymorphisms and lumbar disc degeneration: a scientific overview and meta-analysis.
J Orthop Surg Res. 2018 Mar 05;13(1):47
Authors: Wu H, Wang S, Chen W, Zhan X, Xiao Z, Jiang H, Wei Q
BACKGROUND: An growing variety of research have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha Three chain (COL9A3) gene polymorphisms and the danger of lumbar disc degeneration (LDD). Nonetheless, these research have yielded contradictory outcomes. The aim of this meta-analysis is to analyze the affiliation between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD.
METHODS: All related articles had been collected from PubMed, Net of Science, and China Nationwide Data Infrastructure (CNKI). The final digital search was carried out on September 1, 2017. The allele/genotype frequencies had been extracted from every research. The chances ratio (OR) and 95% confidence interval (CI) had been used to evaluate the power of associations below the 5 comparability genetic fashions. Statistical evaluation was carried out by Assessment Supervisor (RevMan) 5.31 software program.
RESULTS: The meta-analysis of 10 case-control research, together with 2102 LDD circumstances and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms weren’t related to LDD (rs12077871: T vs. C, OR?=?1.85, 95% CI?=?zero.87-Three.91, P?=?zero.11; rs12722877: G vs. C, OR?=?zero.83, 95% CI?=?zero.69-1.01, P?=?zero.06; rs7533552: G vs. A, OR?=?1.11, 95% CI?=?zero.98-1.25, P?=?zero.09; rs61734651: T vs. C, OR?=?1.57, 95% CI?=?zero.51-Four.84, P?=?zero.43). The Egger textual content and the Begg funnel plot didn’t present any proof of publication bias.
CONCLUSION: rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 weren’t considerably related to a predisposition to LDD. Giant-scale and well-designed research are wanted to substantiate this conclusion.
PMID: 29506578 [PubMed – in process]