Cohort examine reveals that peripheral dual-energy X-ray absorptiometry is of restricted epidemiologic use in prepubertal kids.
Acta Paediatr. 2017 Aug;106(eight):1336-1340
Authors: Martins A, Monjardino T, Canhão H, Lucas R
AIM: Peripheral strategies are more and more used to evaluate bone well being, regardless of little proof on their predictive potential. We aimed to judge the usefulness of forearm dual-energy X-ray absorptiometry in prepubertal kids, by estimating the settlement between peripheral and central measures and the flexibility to foretell fracture historical past.
METHODS: In 2012/2014, we assessed 1177 seven-year-old kids from the Technology XXI cohort who had been recruited at beginning in all 5 public hospitals with maternity wards in Porto, Portugal. Subtotal and lumbar backbone bone mineral density (BMD) and content material, left-arm BMD and peripheral forearm BMD had been measured. Dad and mom reported the kid’s lifetime fracture historical past. We estimated settlement utilizing Bland-Altman’s technique and Cohen’s kappa. Fracture prediction potential was calculated utilizing space beneath the receiver operator attribute curve (ROC-AUC).
RESULTS: The boundaries of settlement had been very huge, starting from -2.20/2.20 to -1.87/1.87 normal deviations for the comparability between peripheral and central measures. Categorical settlement was additionally poor, with all kappa values under zero.40. As well as, not one of the measures predicted fractures, as a result of all of the ROC-AUCs had been near zero.50.
CONCLUSION: This examine means that forearm BMD has restricted use for bone well being analysis or as a foundation for medical choices in prepubertal kids.
PMID: 28471502 [PubMed – indexed for MEDLINE]