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Medical end result and prognostic evaluation of meningeal carcinomatosis handled by intrathecal chemotherapy.

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Medical end result and prognostic evaluation of meningeal carcinomatosis handled by intrathecal chemotherapy.

Skilled Rev Pharmacoecon Outcomes Res. 2018 Aug;18(four):455-460

Authors: Meng Z, Zhang Q, Hong Okay, Han W, Zhao Z, Liu Y, He J, Bu H

Summary
OBJECTIVE: To judge the medical efficacy of meningeal carcinomatosis (MC) handled by intrathecal chemotherapy (IC) and analyzes the prognostic elements.
METHODS: The medical and follow-up information of 33 MC sufferers was collected and retrospectively analyzed. Potential prognostic elements corresponding to age, gender, major most cancers, switch time, presence of mind metastasis, intracranial strain, protein, glucose, vascular endothelial progress issue (VEGF), japanese cooperative oncology group (ECOG) efficiency standing (PS), systemic remedy and IC had been mentioned.
RESULTS: The commonest medical manifestation of MC was excessive intracranial strain (30 instances). The adverse price of cerebrospinal fluid cytology was 50% after MC sufferers handled by IC. The remission price of IC and no-IC group was 71.four% and 15.7%, respectively, of which the steadiness price was 92.eight% and 57.eight% with important distinction. The median survival time was 5.200 months (95% CI zero.000-11.491) and the survival price of three, 6, 12 months had been respectively 71.6%, 49.2%, 30.7%.
CONCLUSION: IC can relieve the signs of MC and lengthen life expectancy. Early remedy can enhance prognosis. Presence of mind metastasis, ECOG PS and IC had been correlated with prognosis of sufferers, whereas IC is an unbiased prognostic issue.

PMID: 29745736 [PubMed – indexed for MEDLINE]

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