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Classification of three-dimensional thoracic deformities in adolescent idiopathic scoliosis from a multivariate analysis

PURPOSE: Understanding how to classify and quantify three-dimensional (3D) spinal deformities remains an open question in adolescent idiopathic scoliosis. The objective of this study was to perform a 3D manifold characterization of scoliotic spines demonstrating thoracic deformations using a novel geometric and intuitive statistical tool to determine patterns in pathological cases. METHODS: Personalized 3D reconstructions of thoracic (T)/lumbar (L) spines from a cohort of 170 Lenke Type-1 patients were analyzed with a non-linear manifold embedding algorithm in order to reduce the high-dimensionality of the data, using statistical properties of neighbouring spine models. We extracted sub-groups of the data from the underlying manifold structure using an unsupervised clustering algorithm to understand the inherent distribution and determine classes of pathologies which appear from the low-dimensional space. RESULTS: For Lenke Type-1 patients, four clusters were detected from the low-dimensional manifold of 3D models: (1) normal kyphosis (T) with hyper-lordosis (L) and high Cobb angles (37 cases), (2) low kyphosis (T) and normal lordosis (L), with high rotation of plane of maximum curvature (55 cases), (3) hypo-kyphotic (T) and hyper-lordosis (L) (21 cases) and (4) hyper-kyphotic (T) with strong vertebral rotation (57 cases). Results show the manifold representation can potentially be useful for classification of 3D spinal pathologies such as idiopathic scoliosis and serve as a tool for understanding the progression of deformities in longitudinal studies. CONCLUSIONS: Quantitative evaluation illustrates that the complex space of spine variability can be modeled by a low-dimensional manifold and shows the existence of an additional hyper-kyphotic subgroup from the cohort of 3D spine reconstructions of Lenke Type-1 patients when compared with previous findings on the 3D classification of spinal deformities

Keywords : Adolescent,Algorithms,analysis,Child,classification,Cohort Studies,diagnostic imaging,Female,Humans,Imaging,Three-Dimensional,Kyphosis,Longitudinal Studies,Lordosis,Male,methods,Multivariate Analysis,pathology,Patients,physiology,Predictive Value of Tests,Radiography,Range of Motion,Articular,Reproducibility of Results,Rotation,Scoliosis,Spine,Thoracic Vertebrae,, Threedimensional,Thoracic,Deformities, what kind of doctor treats piriformis syndrome

Date of Publication : 2012 Jan

Authors : Kadoury S;Labelle H;

Organisation : Philips Research North America, 345 Scarborough Rd, Briarcliff Manor, NY 10510, USA. samuel.kadoury@philips.com

Journal of Publication : Eur Spine J

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21879413

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