19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

Chordomas of the Cranium Base, Cell Backbone, and Sacrum: An Epidemiologic Investigation of Presentation, Remedy, and Survival.

Related Articles

Chordomas of the Cranium Base, Cell Backbone, and Sacrum: An Epidemiologic Investigation of Presentation, Remedy, and Survival.

World Neurosurg. 2018 Might;113:e618-e627

Authors: Zuckerman SL, Bilsky MH, Laufer I

BACKGROUND: Chordomas are uncommon main bone tumors that come up from the axial skeleton. Our goal was to research traits in radiation and surgical procedure over time and decide location-based survival predictors for chordomas of the cranium base, cell backbone, and sacrum.
METHODS: A retrospective cohort examine of the SEER (Surveillance Epidemiology and Finish Outcomes) database from 1973 to 2013 was carried out. All sufferers had histologically confirmed chordomas. The principal final result measure was total survival (OS).
RESULTS: The cohort included 1616 sufferers: cranium base (664), cell backbone (444), and sacrum (508). Cranium base tumors offered earliest in life (47.four years) and sacral tumors offered newest (62.7 years). Charges of radiation remained steady for cranium base and cell backbone tumors however declined for sacral tumors (P = Zero.006). Charges of surgical resection remained steady for cranium base and sacral tumors however declined for cell backbone tumors (P = Zero.046). Cranium base chordomas had the longest median survival (162 months) in contrast with cell backbone (94 months) and sacral tumors (87 months). Being married was independently related to improved OS for cranium base tumors (hazard ratio, Zero.73; 95% confidence interval, Zero.53-Zero.99; P = Zero.044). Surgical resection was independently related to improved OS for sacral chordomas (hazard ratio, Zero.48; 95% confidence interval, Zero.34-Zero.69; P < Zero.001).
CONCLUSIONS: Surgical resection for cell backbone chordomas and radiation for sacral chordomas decreased over time. Sufferers with cranium base tumors survived longer than did sufferers with cell backbone and sacral chordomas, and surgical resection was related to improved survival in sacral chordomas solely. Understanding the conduct of those tumors may help cranial and spinal surgeons enhance remedy on this affected person inhabitants.

PMID: 29486315 [PubMed – indexed for MEDLINE]

Share to care...

Share on facebook
Share on twitter
Share on pinterest
Share on google
Share on linkedin
Share on skype

What we do...

The Harley Street Hospital


What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......