Chondrosarcoma of the Osseous Backbone Handled by Surgical procedure With or With out Radiotherapy: A Propensity Rating Matched and Grade/Stage-stratified Research.
Clin Backbone Surg. 2018 Jun 01;:
Authors: Chen D, Chen CH, Zhang LL, Lin ZK, Zheng JW, Phan Ok, Mobbs RJ, Lin Y, Ni WF, Wang XY, Li YM, Wu AM
STUDY DESIGN: This was a longitudinal cohort examine.
OBJECTIVE: The primary goal of this examine was to analyze the outcomes of surgical procedure with or with out radiotherapy throughout remedy of sufferers with chondrosarcoma of the osseous backbone.
SUMMARY OF BACKGROUND DATA: Chondrosarcoma is a major spinal malignant tumor; chemotherapy and radiotherapy (RT) are typically unsuccessful, and thus, the primary remedy of selection is full en bloc resection. Nonetheless, even with full resection, these sufferers nonetheless have a big fee of recurrence, morbidity, and mortality. Though there have been studies that the addition of RT to surgical procedure could result in elevated survival and higher most cancers management, the proof of the efficacy of RT stays controversial.
MATERIALS AND METHODS: Sufferers identified with chondrosarcoma who’re then handled by surgical procedure alone or surgical procedure+RT have been recognized and extracted from the SEER (Surveillance, Epidemiology, and Finish Outcomes) database (1973-2013). Propensity rating matched (PSM) evaluation was carried out to steadiness affected person traits between surgical procedure alone and surgical procedure+RT teams. Sufferers with a distinct grade and stage have been stratified and analyzed.
RESULTS: A complete of 778 sufferers with chondrosarcoma of the osseous backbone handled by surgical procedure alone or surgical procedure+RT have been extracted from the SEER database. Earlier than PSM, the unadjusted Kaplan-Meier curve and bivariable Cox proportional hazard regression fashions confirmed that the surgical procedure alone group had increased chondrosarcoma cancer-specific survival and general survival than the surgical procedure+RT group (each P<zero.zero01), whereas the distinction was attenuated after PSM. Stratified evaluation discovered that RT was worse for low-grade chondrosarcoma sufferers and had a greater development for high-grade chondrosarcoma sufferers.
CONCLUSIONS: The outcomes of our current examine recommend that low-grade chondrosarcoma of the osseous backbone is proof against RT, whereas high-grade chondrosarcoma sufferers had a greater development with RT.
LEVEL OF EVIDENCE: Stage III.
PMID: 29864077 [PubMed – as supplied by publisher]