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Characterization, therapy and prognosis of retinoblastoma with central nervous system metastasis.

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Characterization, therapy and prognosis of retinoblastoma with central nervous system metastasis.

BMC Ophthalmol. 2018 Apr 23;18(1):107

Authors: Hu H, Zhang W, Wang Y, Huang D, Shi J, Li B, Zhang Y, Zhou Y

Summary
BACKGROUND: Retinoblastoma is the most typical main intraocular tumor and increasingly consideration has been paid to the creating nations. This research was aimed to guage the medical options, therapy, and prognosis of retinoblastoma sufferers with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of many largest tertiary eye facilities in China.
METHODS: Medical knowledge of 31 consecutive retinoblastoma sufferers with CNS metastases, who have been identified on the Division of Pediatrics in Beijing Tongren Hospital between September 2005 and December 2015, have been retrospective analyzed.
RESULTS: The median age at presentation was 29 months (vary from 5 to 108 months). Magnetic resonance imaging (MRI) outcomes indicated that 16 sufferers (56.6%, 16/31) offered with meningeal involvement, 12 (38.7%, 12/31) offered with intracranial mass, 11 (35.5%, 11/31) offered with thickened optic nerve, and 5 (16.1%, 5/31) offered with concurrent meningeal and spinal wire membrane involvement. Retinoblastoma cells have been detected within the cerebrospinal fluid (CSF) of 12 sufferers (44.four%, 12/27). Laboratory examinations on the blood and CSF have been carried out for 11 sufferers who had acquired six cycles of systemic chemotherapy, indicated that the serum degree of neurone-specific enolase (NSE) after chemotherapy was considerably decrease than that earlier than chemotherapy (P?< zero.05). On the finish of the follow-up, 25 sufferers have been lifeless with a median survival time of 6 months (1 d – 21 months), and 6 instances have been alive and continued to obtain therapy.
CONCLUSION: Our outcomes have been mainly in step with earlier studies within the creating nations, and it might be steering for medical therapy, prognosis and prevention of CNS metastases in retinoblastoma.

PMID: 29685116 [PubMed – indexed for MEDLINE]

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