Traits of bone turnover markers in quickly harmful coxopathy.
J Bone Miner Metab. 2017 Jul;35(four):412-418
Authors: Abe H, Sakai T, Ogawa T, Takao M, Nishii T, Nakamura N, Sugano N
The aim of this examine was to make clear bone turnover marker ranges in quickly harmful coxopathy (RDC). Twenty sufferers with RDC (imply age, 72 ± 11 years; Three males, 17 postmenopausal girls), 111 with osteoarthritis (OA) (age, 60 ± 10 years; 15 males, 13 premenopausal girls, 83 postmenopausal girls), and 18 with osteonecrosis of femoral head (ON) (55 ± 14 years; 11 males, Three premenopausal girls, four postmenopausal girls), and 100 sufferers with femoral neck fracture (FNF) (81 ± 10 years; 27 males, 73 postmenopausal girls) had been included. Serum tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase (BAP), matrix metalloproteinase-Three (MMP-Three) ranges, and bone mineral density (BMD) of proximal femur and lumbar backbone had been investigated. TRACP-5b ranges had been considerably greater in RDC than in OA and ON, whereas BAP ranges had been greater in RDC than in OA (P < zero.05). MMP-Three ranges had been greater in RDC and ON than in OA (P < zero.05). TRACP-5b had been greater in RDC than OA (P < zero.05) and FNF (P < zero.05) in performing propensity rating matching; there have been no variations in BMD between RDC and OA. TRACP-5b confirmed the most important space below the curve (AUC, zero.82) in line with receiver working attribute (ROC) curve evaluation for diagnosing RDC towards OA and ON. AUCs of BAP and MMP-Three had been zero.78 and zero.74. The respective sensitivities and specificities had been 70.zero % and 85.Three % for TRACP-5b (cutoff, 623 mU/dl), 95.zero % and 57.1 % for BAP (13.eight U/l), and 70.zero % and 76.four % for MMP-Three (52.7 ng/ml). The shortage of variations in BMD recommended that prime bone turnover marker ranges might replicate osteoclast cell activation in RDC hips. Serum TRACP-5b and BAP may very well be RDC markers.
PMID: 27550182 [PubMed – indexed for MEDLINE]