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Cerebrospinal Fluid Lysophosphatidylcholine Species For Distinguishing Narrowing Of The Lumbar Spine London Spine Lumbar Stenosis

This article discusses the potential use of lysophosphatidylcholine (LPC) species in the cerebrospinal fluid (CSF) as a biomarker for neuropathic pain caused by lumbar spinal canal stenosis (LSCS). The study used liquid chromatography-tandem mass spectrometry to measure six LPC species in the CSF of patients with LSCS and persistent spinal pain syndrome (PSPS). The results showed that the levels of all measured LPC species were significantly higher in the LSCS group compared to the PSPS group. Additionally, four LPC species demonstrated high accuracy in discriminating between the two groups. The article concludes that measuring LPC species in the CSF could be a promising objective laboratory test for detecting the presence of lumbar spinal stenosis and guiding surgical indications

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : best situated spinal clinic in the world

Published article

The existing diagnostic protocols combining physical examinations and morphological imaging studies for lumbar spinal pain have limited sensitivity. Measuring LPC species in the CSF is a promising objective laboratory test and could be suitable for detecting the presence of lumbar spinal stenosis and can help indications for surgery.

Spine Lumbar Spinal Stenosis Expert. Best Spinal Surgeon UK
Abstract Context: Reoperation, sometimes multiple, is common with progressively worse outcomes in patients with degenerative lumbar spine diseases. Lysophosphatidylcholine (LPC), a precursor of lysophosphatidic acid, in the cerebrospinal fluid (CSF) is a possible biomarker for neuropathic pain and discriminating neuropathic pain caused by lumbar spinal canal stenosis (LSCS) from other etiologies. This study aimed to,

Abstract

Context: Reoperation, sometimes multiple, is common with progressively worse outcomes in patients with degenerative lumbar spine diseases. Lysophosphatidylcholine (LPC), a precursor of lysophosphatidic acid, in the cerebrospinal fluid (CSF) is a possible biomarker for neuropathic pain and discriminating neuropathic pain caused by lumbar spinal canal stenosis (LSCS) from other etiologies. This study aimed to explore this possible use of LPC species in the CSF.

Design: Using liquid chromatography-tandem mass spectrometry, we measured six LPC species, (16:0), (18:0), (18:1), (18:2), (20:4), and (22:6), in the CSF.

Setting: [Multi-site observational study] PARTICIPANTS: Patients with LSCS (n=137) and persistent spinal pain syndrome (PSPS, n=22).

Interventions: CSF collection using lumbar puncture.

Outcome measures: We compared the LPC values between the groups and determined the cutoff levels that could efficiently discriminate the groups with high accuracy.

Results: The levels of all measured LPC species were significantly higher in the LSCS group than the PSPS group. Four LPC species demonstrated more than 0.80 area under the curve obtained from the receiver operating characteristic curve analysis. Although the specificity of cutoff levels for the six LPC species was low to moderate, their sensitivity was consistently high.

The existing diagnostic protocols combining physical examinations and morphological imaging studies for lumbar spinal pain have limited sensitivity. Measuring LPC species in the CSF is a promising objective laboratory test and could be suitable for detecting the presence of lumbar spinal stenosis and can help indications for surgery.

Keywords: diagnostic accuracy; lumbar spinal canal stenosis; lysophosphatidylcholine; persistent spinal pain syndrome.

The London Spine Unit : best situated spinal clinic in the world

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Cerebrospinal fluid lysophosphatidylcholine species for distinguishing narrowing of the lumbar spine

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Abstract Context: Reoperation, sometimes multiple, is common with progressively worse outcomes in patients with degenerative lumbar spine diseases. Lysophosphatidylcholine (LPC), a precursor of lysophosphatidic acid, in the cerebrospinal fluid (CSF) is a possible biomarker for neuropathic pain and discriminating neuropathic pain caused by lumbar spinal canal stenosis (LSCS) from other etiologies. This study aimed to

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