Cell Remedy as a New Strategy to the Therapy of Posttraumatic Syringomyelia.
World Neurosurg. 2017 Nov;107:1047.e5-1047.e8
Authors: Vaquero J, Hassan R, Fernández C, Rodríguez-Boto G, Zurita M
BACKGROUND: Cell transplantation with autologous bone marrow-derived mesenchymal stromal cells (MSCs) appears to be a therapeutic promise for sufferers with established spinal wire harm, attaining enchancment of their high quality of life, however there isn’t a expertise with the applying of one of these cell remedy in sufferers struggling posttraumatic syringomyelia.
OBJECTIVE: To check the doable utility of cell remedy with autologous MSCs in posttraumatic syringomyelia.
METHODS: A 40-year-old man with full paraplegia since 1991 as a consequence of a Th4 vertebral fracture confirmed an important posttraumatic syringomyelia that prolonged as much as C2 vertebral degree, with out indicators of latest worsening. Autologous MSCs (150 × 106) had been injected into the syrinx, with out drainage or aspiration.
RESULTS: One 12 months after cell remedy, syrinx was diminished with out collapse of cervical spinal wire. In the course of the course of follow-up, clear scientific enchancment was noticed, primarily in sphincter dysfunction.
CONCLUSIONS: Injection of MSCs within the syrinx of posttraumatic syringomyelia is secure and is related to scientific and neuroimaging enchancment. The opportunity of cell remedy as a brand new method to posttraumatic syringomyelia, and even for idiopathic syringomyelia, is an open door that requires additional examine.
PMID: 28804041 [PubMed – indexed for MEDLINE]