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Cauda equine syndrome as the first symptom of leptomeningeal metastases from lung most cancers: a case report and evaluation of literature.

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Cauda equine syndrome as the first symptom of leptomeningeal metastases from lung most cancers: a case report and evaluation of literature.

Onco Targets Ther. 2018;11:5009-5013

Authors: Liu Y, Wang B, Qian Y, Di D, Wang M, Zhang X

Cauda equine syndrome (CES) is a neurological situation brought on by compression of the cauda equine. Right here, we show a case of CES as the first symptom of leptomeningeal metastases from non-small cell lung carcinoma with out mind metastases. A 59-year-old male suffered progressive decrease extremity motor dysfunction, urinary dysfunction, and decrease extremity sensory dysfunction. He was clinically identified with CES. Nuclear magnetic resonance imaging demonstrated a number of imprecise nodules within the space of conus medullaris and cauda equine, with out lumbar or thoracic herniated discs. The serum carcinoembryonic antigen focus was 191.20 ng/mL. The conclusion following positron emission tomography-computed tomography was a proper higher lung malignant tumor with mediastinal lymph node metastasis and cauda equina metastasis. Pathologic prognosis was of main adenocarcinoma of the lung by bronchoscopic biopsy. EML4-ALK fusion and EGFR mutations had been absent, and thus the affected person acquired chemotherapy. Nonetheless, signs of intracranial hypertension arose 1 month later, and the affected person died three months postadmission. Rising CES could also be an indication of metastasis of a malignant tumor, presenting a particularly difficult situation, particularly for sufferers with lung most cancers. Positron emission tomography-computed tomography is a reasonably efficient method to make the prognosis.

PMID: 30174438 [PubMed]

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