Canine spinal nephroblastoma: long-term outcomes associated with treatment of 10 cases (1996-2009)

OBJECTIVE: To report clinical outcome associated with treatment of canine spinal cord nephroblastoma (CSN). STUDY DESIGN: Case series. ANIMALS: Dogs (n=10) with histopathologically confirmed CSN. METHODS: Records of dogs with CSN were reviewed and clinicopathologic, diagnostic imaging, treatment, outcome, and survival data were collected. RESULTS: CSN resulted in clinical signs of chronic, progressive T3-L3 myelopathy in young, large breed dogs, with an overrepresentation of German Shepherd Dogs (n=4). All CSN were located between T9 and L2. Dogs treated with cytoreductive surgery (n=6) or radiotherapy (1) survived longer (median, 374 days; range, 226-560 days) than dogs treated palliatively (3; median, 55 days; range, 38-176 days). Tumors confined to an intradural-extramedullary (ID-EM) location were associated with superior survival (n=6; median, 380 days; range, 176-560 days) than tumors with intramedullary (IM) involvement (n=4; median, 140 days; range, 38-269 days). Treatment resulted in temporary improvement in neurologic function in 9 dogs, including all dogs treated surgically, but local disease progression resulted in death of 8 dogs. CONCLUSIONS: Results of this observational study suggest that surgical cytoreduction and radiotherapy are effective at improving survival in dogs with CSN, and that ID-EM tumors may be associated with a more favorable prognosis than IM neoplasms

Keywords : Animals,Combined Modality Therapy,diagnosis,diagnostic imaging,Disease Progression,Dog Diseases,Dogs,Fatal Outcome,Female,Male,methods,Neoplasms,pathology,Prognosis,radiotherapy,Retrospective Studies,Spinal Cord,Spinal Cord Neoplasms,surgery,therapy,Treatment Outcome,veterinary,Wilms Tumor,, Spinal,Nephroblastoma,Longterm,Outcomes,Associated, slipped disc mri scan

Date of Publication : 2011 Feb

Authors : Liebel FX;Rossmeisl JH;Lanz OI;Robertson JL;

Organisation : Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA

Journal of Publication : Vet Surg

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21223320

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