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Caffeic acid phenethyl ester reduces spinal cord injury-evoked locomotor dysfunction

Caffeic acid phenethyl ester (CAPE) is a component of propolis, which is a substance taken from the hives of honeybees, and is known to exhibit an anti-inflammatory activity. Such activity has been thought to be partly based on its potential and specific inhibitory activities toward nuclear factor-kappaB, a transcription factor. Therefore, in the present study, we evaluated the effect of CAPE on functional locomotor recovery after spinal cord injury (SCI) caused by hemi-transection, because inflammatory responses are a major cause of the secondary injury observed following SCI and play a pivotal role in regulating the pathogenesis of acute and chronic SCI. When CAPE was i.p.-administered at a dosage of 10 micromol/kg, it enhanced the recovery of locomotor function and reduced the lesion size while suppressing the expression of the mRNAs for a pro-inflammatory cytokine interleukin-1beta and the inflammatory enzymes, inducible nitric oxide synthase and cyclooxygenase-2. These results suggest CAPE to be a promising therapeutic tool for reducing the secondary neuronal damage following primary physical injury to the spinal cord

Keywords : administration & dosage,analogs & derivatives,Animals,Anti-Inflammatory Agents,Caffeic Acids,Cyclooxygenase 2,Down-Regulation,drug effects,drug therapy,Female,genetics,injuries,Interleukin-1beta,metabolism,Nitric Oxide Synthase Type II,pathology,Phenylethyl Alcohol,physiopathology,Rats,Rats,Wistar,Spinal Cord,Spinal Cord Injuries,Spinal Cord Regeneration,Thoracic Vertebrae,Transcription,Genetic,, Acid,Phenethyl,Ester,Reduces,Spinal, back pain physiotherapy

Date of Publication : 2011 Feb

Authors : Kasai M;Fukumitsu H;Soumiya H;Furukawa S;

Organisation : Laboratory of Molecular Biology, Gifu Pharmaceutical University, Japan

Journal of Publication : Biomed Res

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21383505

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