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Cadaveric Biomechanical Studies Of ADDISC Total Lumbar Disc Prosthesis – Lumbar Disc Replacement

The article discusses a study conducted on cadaveric lumbosacral spines to determine if a new lumbar disc prosthesis can mimic the movement and kinematics of a natural intervertebral disc. The researchers found that the prosthesis was able to replicate the Instantaneous Center of Rotation, but there were significant differences in lateral bending and right rotation compared to the intact spine. The study also found that the prosthesis failed to restore the initial range of motion due to ligament destabilization. The researchers suggest that further studies are needed to develop techniques that can restore the damaged ligaments during prosthesis implantation. Keywords associated with the study include degenerative disc disease, motion preservation, range of motion, and total disc replacement

Summarised by Mr Mo Akmal – Lead Spinal Surgeon
The London Spine Unit : most experienced treatment clinic in the world

Published article

BACKGROUND: Most total disc replacements provide excessive mobility and not reproduce spinal kinematics, inducing zygapophyseal joint arthritic changes and chronic back pain. In cadaveric lumbosacral spines, we studied if a new lumbar disc prosthesis kinematics mimics the intact intervertebral disc.

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Abstract Background: Most total disc replacements provide excessive mobility and not reproduce spinal kinematics, inducing zygapophyseal joint arthritic changes and chronic back pain. In cadaveric lumbosacral spines, we studied if a new lumbar disc prosthesis kinematics mimics the intact intervertebral disc. Methods: In eight cold preserved cadaveric lumbosacral spines, we registered the movement ranges in,

Abstract

Background: Most total disc replacements provide excessive mobility and not reproduce spinal kinematics, inducing zygapophyseal joint arthritic changes and chronic back pain. In cadaveric lumbosacral spines, we studied if a new lumbar disc prosthesis kinematics mimics the intact intervertebral disc.

Methods: In eight cold preserved cadaveric lumbosacral spines, we registered the movement ranges in flexion, extension, right and left lateral bending, and rotation in the intact status, post-discectomy, and after our prosthesis implantation, comparing them for each specimen.

Findings: Comparing the intact lumbosacral spine with the L4-L5 prosthesis implanted specimens, we saw statistically significant differences in lateral bending and right rotation but not in the full range of rotation. Analyzing segments, we also noticed statistically significant differences at L4-L5 in flexion-extension and rotation. On the other hand, the L4-L5 discectomy, compared to the baseline spine condition, showed a statistically significant mobility increase in flexion, extension, lateral bending, and axial rotation, with an abnormal instantaneous center of rotation, which destabilizes the segment partly due to anterior annulus surgical removal. Disc prosthesis implantation reversed these changes in instantaneous center of rotation, but the prosthesis failed to restore the initial range of motion due to the destabilization of the ligaments in the operated disc.

Interpretation: The ADDISC total disc replacement reproduces the intact disc kinematics and Instantaneous Center of Rotation, but the prosthesis fails to restore the initial range of motion due to ligament destabilization. More studies will be necessary to define a technique that restores the damaged ligaments when implanting the prosthesis.

Keywords: Degenerative disc disease; Motion preservation; Polycarbonate urethane; Range of motion; Total disc arthroplasty; Total disc replacement.

The London Spine Unit : most experienced treatment clinic in the world

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Cadaveric biomechanical studies of ADDISC total lumbar disc prosthesis

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Abstract Background: Most total disc replacements provide excessive mobility and not reproduce spinal kinematics, inducing zygapophyseal joint arthritic changes and chronic back pain. In cadaveric lumbosacral spines, we studied if a new lumbar disc prosthesis kinematics mimics the intact intervertebral disc. Methods: In eight cold preserved cadaveric lumbosacral spines, we registered the movement ranges in

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