[Bone quality in patients with acromegaly].
Vnitr Lek. Fall 2017;63(9):589-592
Authors: Kužma M, Ságová I, Pavai D, Jackuliak P, Killinger Z, Va?uga P, Payer J
The affect of acromegaly on bone and the chance of fractures has not been sufficiently investigated. GH hypersecretion stimulates bone turnover, resulting in a rise in bone turnover markers. Regular and even elevated bone mineral density (BMD) compared to wholesome controls have been reported, however there are some works the place decreased BMD was noticed amongst acromegaly sufferers with hypogonadism, significantly at lumbar backbone. Much less pronounced impact of GH overproduction was noticed on the femoral neck, as defined by the optimistic impact of hypersecretion on the cortical bone (as a consequence of periosseal ossification). A number of research have documented morphometric vertebral fractures (VF) in 1/three of acromegaly sufferers. The main threat components resulting in the event of VF embody hypogonadism, diabetes mellitus and former VF. As a result of the chance of fractures doesn’t correlate with BMD many of the research are at present targeted on bone high quality, bone power and microstructure.Key phrases: bone microstructure – development hormone – IGF1 – vertebral fractures.
PMID: 29120655 [PubMed – indexed for MEDLINE]