Bone Mineral Density in Girls Residing with Full Androgen Insensitivity Syndrome and Intact Testes or Eliminated Gonads.
Intercourse Dev. 2017;11(four):182-189
Authors: Bertelloni S, Meriggiola MC, Dati E, Balsamo A, Baroncelli GI
Full androgen insensitivity syndrome (CAIS) is because of full androgen resistance in androgen-dependent tissues. Since androgens are concerned in progress, growth, and mass upkeep of the skeleton, bone well being could also be a related medical problem for bettering high quality of life of ladies dwelling with CAIS. Bone mineral density (BMD) in ladies with CAIS and intact gonads has been reported in a traditional vary, though exceptions are recognized exhibiting a low BMD primarily on the lumbar degree. In ladies with CAIS and eliminated gonads, BMD is often lowered at each the lumbar backbone and femoral neck. Nevertheless, the fracture threat stays largely unknown. In ladies with CAIS, hormonal alternative remedy might enhance BMD, but it surely doesn’t normalize it. A number of components could also be operative (e.g., lack of AR signaling on the bone degree, gonadal removing, and age at surgical procedure [before or after attainment of the peak bone mass], insufficient intercourse steroid alternative remedy, poor compliance with hormonal therapy, excessive serum FSH ranges, lack of testicular protein hormones after gonadal removing), however they’re poorly evaluated. In conclusion, the upkeep of testes might signify a technique to enhance bone well being in ladies with CAIS, however a strict follow-up to watch the most cancers threat is necessary primarily from their 20s onwards. Optimum intercourse steroid substitutive remedy in adolescence and maturity is a key issue to enhance BMD standing in ladies with CAIS and eliminated gonads, however conclusive knowledge on optimum administration are missing.
PMID: 28715798 [PubMed – indexed for MEDLINE]