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Bone Metabolism in a Giant Cohort of Sufferers with Systemic Sclerosis.
Calcif Tissue Int. 2016 Jul;99(1):23-9
Authors: Caimmi C, Caramaschi P, Barausse G, Orsolini G, Idolazzi L, Gatti D, Viapiana O, Adami S, Biasi D, Rossini M
Summary
The intention of this examine was to guage in a big measurement cohort of SSc sufferers bone mineral density (BMD) and to research its doable determinants. 106 consecutive outpatients affected by SSc have been enrolled and fully evaluated for bone metabolism and SSc traits. For the statistical evaluation, we most popular Z rating to BMD or T rating for the reason that inhabitants was composed of sufferers of various ages and of each sexes. Imply neck Z rating was considerably decrease than zero. No important variations have been discovered for different websites. Feminine sufferers have been proven to have a complete femur and neck Z rating considerably decrease than zero (p = zero.028 and p < zero.001, respectively). 13 % of sufferers had a minimum of one morphometric non-clinical vertebral fracture. In univariate evaluation, complete femur Z rating was decrease in feminine (p = zero.050) and positively correlates with BMI (p = zero.001), neck Z rating positively correlates with age (p = zero.016), and entire physique Z rating positively correlates with BMI (p < zero.001). No correlations have been discovered for lumbar Z rating. The multivariate evaluation confirmed the optimistic correlation between BMI and complete femur and entire physique Z rating and between age and neck femur Z rating (p = zero.005, p < zero.001 and p = zero.040, respectively). Lung involvement was proven to correlate with a decrease entire physique Z rating in multivariate evaluation (p = zero.037). We discovered a modest danger of low BMD in sufferers with SSc and the vital protecting function of BMI. Sufferers with lung involvement confirmed decrease entire physique Z rating.
PMID: 26898382 [PubMed – indexed for MEDLINE]