Bone involvement in grownup sufferers affected with Ehlers-Danlos syndrome.
Osteoporos Int. 2016 Aug;27(eight):2525-31
Authors: Eller-Vainicher C, Bassotti A, Imeraj A, Cairoli E, Ulivieri FM, Cortini F, Dubini M, Marinelli B, Spada A, Chiodini I
UNLABELLED: The Ehlers-Danlos syndrome is characterised by irregular connective tissue however bone involvement is debated. We discovered a diminished BMD and bone high quality and elevated prevalence of asymptomatic vertebral fractures in eugonadal sufferers with Ehlers-Danlos syndrome. These findings recommend the necessity of a bone well being analysis in these sufferers.
INTRODUCTION: The Ehlers-Danlos (EDS) syndrome is characterised by abnormalities of the connective tissue resulting in ligamentous laxity and pores and skin and tissue fragility. We evaluated the bone metabolism, bone mineral density (BMD) and bone high quality (measured by trabecular bone rating, TBS), and the prevalence of vertebral fractures (VFx) in a gaggle of eugonadal grownup EDS sufferers.
METHODS: Fifty consecutive Caucasian sufferers, aged 30-50 years (36 females, 14 males) with classical or hypermobility EDS and 50 age-, gender-, and physique mass index (BMI)-matched management topics have been enrolled. In all topics’ calcium-phosphorous metabolism, bone turnover, BMD on the lumbar backbone (LS) and femur (femoral neck, FN and whole femur, FT) and TBS by dual-energy X-ray absorptiometry, and the VFx presence by backbone radiograph have been assessed.
RESULTS: Sufferers confirmed diminished BMD (Z-scores LS -Zero.45?±?1.00, FN -Zero.56?±?1.01, FT -Zero.58?±?Zero.92) and TBS (1.299?±?Zero.111) and elevated prevalence of morphometric VFx (32 %) than controls (Z-scores LS Zero.09?±?1.22, FN Zero.01?±?Zero.97, FT Zero.08?±?Zero.89; TBS 1.382?±?Zero.176; VFx eight %, p <Zero.05 for all comparisons), whereas vitamin D ranges, calcium-phosphorous metabolism, and bone turnover have been comparable. Fractured EDS sufferers confirmed decrease TBS values than non-fractured ones (1.245?±?Zero.138 vs 1.325?±?Zero.086, p?<?Zero.05), regardless of comparable BMD. In EDS sufferers, the VFx presence was considerably related to TBS even after adjusting for intercourse, age, BMD, EDS kind, and falls frequency.
CONCLUSIONS: EDS sufferers have diminished BMD and bone high quality (as measured by TBS) and elevated prevalence of VFx.
PMID: 27084695 [PubMed – indexed for MEDLINE]