Computerized remedy planning facilitates quick era of high-quality remedy plans for esophageal most cancers.
Acta Oncol. 2017 Nov;56(11):1495-1500
Authors: Hansen CR, Nielsen M, Bertelsen AS, Hazell I, Holtved E, Zukauskaite R, Bjerregaard JK, Brink C, Bernchou U
BACKGROUND: The standard of radiotherapy planning has improved considerably within the final decade with the introduction of depth modulated radiotherapy. The aim of this examine was to investigate the plan high quality and efficacy of routinely (AU) generated VMAT plans for inoperable esophageal most cancers sufferers.
MATERIAL AND METHODS: Thirty-two consecutive inoperable sufferers with esophageal most cancers initially handled with manually (MA) generated volumetric modulated arc remedy (VMAT) plans had been retrospectively replanned utilizing an auto-planning engine. All plans had been optimized with one full 6MV VMAT arc giving 60?Gy to the first goal and 50?Gy to the elective goal. The planning methods had been blinded earlier than medical analysis by three specialised oncologists. To complement the medical analysis, the optimization time for the AU plan was recorded together with DVH parameters for all plans.
RESULTS: Upon medical analysis, the AU plan was most well-liked for 31/32 sufferers, and for one affected person, there was no distinction within the plans. When it comes to DVH parameters, comparable goal protection was obtained between the 2 planning strategies. The imply dose for the spinal wire elevated by 1.eight?Gy utilizing AU (p?=?.002), whereas the imply lung dose decreased by 1.9?Gy (p?<?.001). The AU plans had been extra modulated as seen by the rise of 12% in imply MUs (p?=?.001). The median optimization time for AU plans was 117?min.
CONCLUSIONS: The AU plans had been basically most well-liked and confirmed a decrease imply dose to the lungs. The automation of the planning course of generated esophageal most cancers remedy plans shortly and with prime quality.
PMID: 28840767 [PubMed – indexed for MEDLINE]