Menu
Menu
19 Harley St, London, W1G 9QJ, UK
We are London's Top Spine Clinic

Association between baseline IL-6 and 1-year recovery in lumbar radicular pain.

Related Articles

Association between baseline IL-6 and 1-year recovery in lumbar radicular pain.

Eur J Pain. 2014 Apr 2;

Authors: Schistad EI, Espeland A, Pedersen LM, Sandvik L, Gjerstad J, Røe C

Abstract
BACKGROUND: In the present study, the influence of cytokines on 1-year recovery in lumbar radicular pain was examined.
METHODS: In total, 110 patients with symptomatic lumbar disc herniation were followed for 1 year. Uni- and multivariate linear regression was used to assess the influence of interleukin (IL)-6, IL-8, disc degeneration and endplate changes (Modic changes) on the changes in the Oswestry Disability Index (ODI change; primary outcome) and visual analogue scale (VAS) for low back pain (LBP) and leg pain (secondary outcomes).
RESULTS: Less favourable ODI outcome correlated with higher serum IL-6 levels (B?=?-3.41, 95% CI -5.52 to -1.30, p?=?0.002), non-surgical treatment (B?=?-7.03, 95% CI 1.21 to 12.84, p?=?0.018), higher baseline back pain intensity (B?=?-2.28, 95% CI -3.21 to -1.35, p?<?0.001) and low educational level (B?=?-5.57, 95% CI 0.66 to 10.47, p?=?0.027). High VAS for LBP and leg pain at 1 year was associated with high levels of serum IL-6, higher back pain intensity and longer duration of lumbar radicular pain at baseline.
CONCLUSIONS: High serum IL-6 levels, but not disc degeneration or Modic changes, were associated with less favourable recovery in patients with lumbar radicular pain. Intense initial back pain, non-surgical treatment, lower educational level and longer duration of radicular pain before treatment also correlated with a slower recovery the first year after disc herniation.

PMID: 24692238 [PubMed – as supplied by publisher]

Share to care...

Share on facebook
Facebook
Share on twitter
Twitter
Share on pinterest
Pinterest
Share on google
Google+
Share on linkedin
LinkedIn
Share on skype
Skype

What we do...

The Harley Street Hospital

Testimonials

What is London spine unit and How it Works

The London Spine Unit was established in 2005 and has successfully treated over 5000 patients. All conditions are treated.

We treat all spinal disorders

The London Spine Unit specialises in Minimally Invasive Treatments allowing rapid recovery and return to normal function

Trusted by patients worldwide

The London Spine Unit provides the highest quality care to all patients and has VIP services for those seeking exceptional services

What our patients say about us ......