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[Application value of Xpert MTB/RIF in diagnosis of spinal tuberculosis and detection of rifampin resistance].

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[Application value of Xpert MTB/RIF in diagnosis of spinal tuberculosis and detection of rifampin resistance].

Zhongguo Gu Shang. 2017 Sep 25;30(9):787-791

Authors: Jin YH, Shi SY, Zheng Q, Shen J, Ying XZ, Wang YF

Summary
OBJECTIVE: To analyze the appliance worth of Xpert MTB/RIF in analysis of spinal tuberculosis and detection of rifampin resistance.
METHODS: The 109 pus specimens had been obtained from sufferers who had been primaryly identified as spinal tuberculosis. All the pus specimens had been detected by acid-fast stain, liquid quick culturing by BACTEC MGIT 960 and Xpert MTB/RIF assay to particular the variations in sensitivity and specificity of mycobacterium tuberculosis amongst detecting strategies. Pus specimens obtained by totally different strategies had been deteceded by MTB/RIF check to investigate the self-influence on Xpert MTB/RIF check. The results of liquid quick culturing by BACTEC MGIT 960 was used because the gold commonplace; and the worth of Xpert MTB/RIF assay in detecting rifampin resistance was analyzed.
RESULTS: The sensitivity of acid-fast stain, liquid quick culturing by BACTEC MGIT 960 and Xpert MTB/RIF assay had been 25.92%, 48.15%, 77.78%, respectively. The sensitivity of pus specimens obtained from open surgical procedure, ultrasound positioning puncture and biopsy the sensitivity had been 83.78%, 76.47%, 44.68% respectively deteceded by MTB/RIF check. In keeping with the gold commonplace of the outcomes of liquid quick culturing by BACTEC MGIT 960 assay, the sensitivity and specificity of Xpert MTB/RIF assay in detecting rifampin resistance had been 80%(four/5) and 90.70%(39/43), respectively.
CONCLUSIONS: Xpert MTB/RIF assay has greater worth in analysis of spinal tuberculosi, and in addition can detect rifampin resistance. The variety of mycobacterium tuberculosis in pus specimens has a terrific affect within the sensitivity of Xpert MTB/RIF assay.

PMID: 29455477 [PubMed – indexed for MEDLINE]

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