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Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain

Symptoms of neuropathic spinal cord injury (SCI) pain include evoked cutaneous hypersensitivity and spontaneous pain, which can be present below the level of the injury. Adverse side-effects obtained with currently available analgesics complicate effective pain management in SCI patients. Voltage-gated Na(+) channels expressed in primary afferent nociceptors have been identified to mediate persistent hyperexcitability in dorsal root ganglia (DRG) neurons, which in part underlies the symptoms of nerve injury-induced pain. Ambroxol has previously demonstrated antinociceptive effects in rat chronic pain models and has also shown to potently block Na(+) channel current in DRG neurons. Ambroxol was tested in rats that underwent a mid-thoracic spinal cord compression injury. Injured rats demonstrated robust hind paw (below-level) heat and mechanical hypersensitivity. Orally administered ambroxol significantly attenuated below-level hypersensitivity at doses that did not affect performance on the rotarod test. Intrathecal injection of ambroxol did not ameliorate below-level hypersensitivity. The current data suggest that ambroxol could be effective for clinical neuropathic SCI pain. Furthermore, the data suggest that peripherally expressed Na(+) channels could lend themselves as targets for the development of pharmacotherapies for SCI pain

Keywords : Ambroxol,Analgesics,Animals,Behavior,Animal,complications,drug effects,drug therapy,etiology,Hot Temperature,Hyperalgesia,Injections,Spinal,injuries,Male,Motor Activity,Neuralgia,Neurons,Nociceptors,Pain,Pain Management,Pain Measurement,Pain Threshold,Paralysis,pharmacology,Physical Stimulation,Postural Balance,psychology,Rats,Rats,Sprague-Dawley,Sodium Channel Blockers,Spinal Cord,Spinal Cord Compression,Spinal Cord Injuries,, Effect,Ambroxol,Rats, back consultant

Date of Publication : 2010 Dec

Authors : Hama AT;Plum AW;Sagen J;

Organisation : The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. ahama@med.miami.edu

Journal of Publication : Pharmacol Biochem Behav

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/20732348

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