[Antiinflammatory treatment in patients with chronic back pain].
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12):46-51
Authors: Gaydukova IZ, Bichurina DM, Popova YR, Rebrov AP
Summary
Non-steroidal anti-inflammatory medicine (NSAIDs) are a part of the remedy of sufferers with continual nonspecific again ache (CBP). An evaluation of the explanations for the absence of NSAIDs administration or cancellation of beforehand iniciated NSAIDs in sufferers with CBP was the purpose of this research.
MATERIAL AND METHODS: We analyzed the peculiarities of remedy of CBP in 250 sufferers at baseline and after 1 and a pair of years. The options of drug remedy, the explanations for remedy cancellation have been evaluated.
RESULTS AND CONCLUSION: 52 (20.eight%) of sufferers with CBP weren’t handled with NSAIDs, 38 (15.2%) recieved NSAIDs in four and > days per week, 44 (17.6%) – three and < days every week, 62 (24.eight%) took NSAID in 7-14 day 2-5 occasions per yr, 54 (21.6%) – in on-demand mode. Absence of NSAIDs administration in CBP was related to older age, the presence of comorbidites, with non-alcoholic fatty liver illness and weight problems. The cancelletion of beforehand initiated NSAID was equally related to the decision of ache and with the failure to answer remedy, with the presence of weight problems and with the consumption of nonselective NSAIDs. Continuation of the initiated efficient anti-inflammatory remedy was related to using coxibs, advanced remedy with using neirobion, with the presence of regular physique weight, and with the achievement of a lower within the severity of the ache syndrome even within the absence of its full decision. Elevated adherence to remedy with NSAIDs in CBP sufferers might be achieved by growing of its effectiveness by means of using NSAIDs (particularly coxibs) with B group nutritional vitamins (B1, B6, B12), by normalizing of BMI and successfully controlling liver operate.
PMID: 29376983 [PubMed – in process]