19 Harley St, London, W1G 9QJ, UK

Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation model

STUDY DESIGN: An experimental animal study. OBJECTIVE: We evaluated the efficacy of lactoferrin (LF) compared with diclofenac to reduce the pain, using a rat lumbar disc herniation model. SUMMARY OF BACKGROUND DATA: LF is a multifunctional protein that is found in milk. Recent studies have reported that LF reduces nociception in various experimental models. METHODS: Rats were operated on the left L5 vertebral arch. The left L5 nerve root and dorsal root ganglion (DRG) were exposed by a L5 partial laminectomy. An L-shaped stainless steel rod was inserted from the laminectomy toward the intervertebral foramen to compress the nerve root. In addition, nucleus pulposus from coccygeal discs was applied on the nerve root. At 1 day before operation, all rats were tested regarding the withdrawal threshold of the left plantar surface using von Frey filaments to determine baseline values. Additional von Frey tests were performed on postoperative days 3, 7, 14, and 21. Thirty minutes before each test except for baseline, the rats received LF (100 mg/kg), diclofenac (10 mg/kg), or saline by intraperitoneal injection (n = 6). RESULTS: As compared with the control group, thresholds of rats in the diclofenac group were significantly higher on postoperative days 3 and 7. However, on postoperative days 14 and 21, there were no significant differences. Thresholds of rats in the LF group were significantly higher on all postoperative days compared with the control group. CONCLUSION: Analgesic effect of diclofenac reduced with time. However, the effect of LF continued during the whole experimental period. LF might become useful as pain-killer

Keywords : administration & dosage,Analgesics,Animals,Cattle,chemistry,complications,Diclofenac,Disease Models,Animal,drug effects,drug therapy,etiology,Intervertebral Disc Displacement,Lactoferrin,Laminectomy,Low Back Pain,Male,methods,Milk,Pain,Pain Threshold,physiology,Radiculopathy,Rats,Rats,Sprague-Dawley,Spinal Nerve Roots,surgery,, Effect,Bovine,Milkderived,Lactoferrin, synovitis causes

Date of Publication : 2010 Aug 15

Authors : Sasaki N;Sekiguchi M;Kikuchi S;Konno S;

Organisation : Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan. non@fmu.ac.jp

Journal of Publication : Spine (Phila Pa 1976 )

Pubmed Link : https://www.ncbi.nlm.nih.gov/pubmed/21374893

The London Spine Unit : Harley Street UK. Specialists in Cutting Edge Technologies for Spinal Surgery

Make an Appointment 

Trustpilot Reviews
Doctify Reviews
Top Doctor Reviews

Doctors Specialising in Nerve Root Injections
Mr Mo Akmal MD
Mr Mo Akmal, MD, stands as a innovator in the ...

Related Posts

0/5 (0 Reviews)

Trusindex Reviews

London Spine Unit Harley Street Hospital

A Focus on High Quality Specialised Care

We are a specialist Private Hospital based on Harley Street, London UK The Harley Street Hospital, Day Surgery Hospital

We provide exclusive health services for individuals seeking Advanced medical, non-surgical or minimally invasive treatments. We are covered by All Insurance Companies apart from AXA PPP

Our Medical Director and Lead Spinal Surgeon Mr Mo Akmal MD is a world renowned Spine Specialist Consultant with over 20 years of experience. He and his team have developed revolutionary techniques to perform all types of Spinal Surgery as a Day Case procedure without traditional General Anaesthetic.

We are constantly improving our techniques for treatment and improving facilities for our patients.

Book your Appointment Now 
Check out our Reviews 
Check out our Patient Videos 
Check our Mr Akmal’s Profile

 

What our patients say ...

Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation model | Repetitive strain injury symptoms in hand

Revolutionary Keyhole surgical technique to vaporise bulging discs

Dr Mo Akmal Medical Director
Dr Mo Akmal MD - Lead Spinal Surgeon

Laser Disc Surgery can be performed under local anaesthetic at The Harley Street Hospital.

Initial Consultation

with Consultant Spine Surgeon
£ 250
  • No Waiting Times
  • Top NHS affiliated Consultant
  • Includes Clinical Review and Report
  • Multidisciplinary discussion
  • Review of Previous Scans and Reports

Follow up Consultation

any appointment after initial consultation
£ 180
  • Top NHS affiliated Consultant
  • Includes Clinical Review and Report
  • Multidisciplinary discussion

High Resolution MRI Scan

any Single Region (3.0 Tesla)
£ 600
  • No waiting times
  • Includes Full Radiologist Report
  • Open or Closed MRI scan types
  • Copy of Scan on CD

Website Offer

Pre-Booked Online
£1130
£ 800
  • Initial Consultation
  • MRI Scan (Single Region)
  • Follow Up consultation
  • Same Day One Stop Visit
  • Full Medical and MRI scan Report
  • Copy of scan on CD
Popular

If you have any emergency Doctor’s need, simply call our 24 hour emergency

Your personal case manager will ensure that you receive the best possible care.

Call Now 

+44 844 589 2020
+44 203 973 8810