An aged affected person presenting with a main spinal multifocal intradural extramedullary pilocytic astrocytoma: a case report and evaluation of the literature.
BMC Most cancers. 2018 Aug 09;18(1):806
Authors: McBride D, Aljuboori Z, Hattab EM, Downs R, Woo S, Williams B, Neimat J, Burton E
BACKGROUND: Pilocytic astrocytoma is a low-grade central nervous system tumor mostly seen in youngsters. Dissemination from a main intracranial tumor alongside the neuroaxis has been described at each presentation and illness development. Nevertheless, the event of an intradural extramedullary pilocytic astrocytoma impartial of a main intraparenchymal tumor in an grownup affected person with no historical past of pilocytic astrocytoma has not often been reported.
CASE PRESENTATION: A 69-year-old lady introduced with progressive myelopathic signs and thoracic radicular ache. MRI imaging of the entire backbone confirmed an enhancing intradural extramedullary lesion extending from the cervical wire to T11 inflicting wire compression. Laminectomies had been carried out for surgical decompression and histopathology was in step with pilocytic astrocytoma. Full staging was completed that included imaging of the mind and cerebrospinal fluid cytology. No different tumor was discovered by these strategies. Postoperatively the affected person was handled with giant discipline spinal radiation and concurrent chemotherapy adopted by adjuvant chemotherapy. She has so far been clinically and radiographically steady.
CONCLUSION: This can be a uncommon case of an grownup with a number of spinal pilocytic astrocytomas in an intradural extramedullary location, sometimes the results of cerebrospinal fluid dissemination of neoplastic cells from a main intracranial tumor web site (i.e. drop metastasis). No standard main tumor was recognized on this affected person, suggesting these tumors could come up from heterotopic gliomas.
PMID: 30092761 [PubMed – in process]