An aged affected person presenting with a major spinal multifocal intradural extramedullary pilocytic astrocytoma: a case report and evaluate of the literature.
BMC Most cancers. 2018 Aug 09;18(1):806
Authors: McBride D, Aljuboori Z, Hattab EM, Downs R, Woo S, Williams B, Neimat J, Burton E
BACKGROUND: Pilocytic astrocytoma is a low-grade central nervous system tumor mostly seen in youngsters. Dissemination from a major intracranial tumor alongside the neuroaxis has been described at each presentation and illness development. Nevertheless, the event of an intradural extramedullary pilocytic astrocytoma impartial of a major intraparenchymal tumor in an grownup affected person with no historical past of pilocytic astrocytoma has hardly ever been reported.
CASE PRESENTATION: A 69-year-old lady introduced with progressive myelopathic signs and thoracic radicular ache. MRI imaging of the entire backbone confirmed an enhancing intradural extramedullary lesion extending from the cervical wire to T11 inflicting wire compression. Laminectomies have been carried out for surgical decompression and histopathology was in step with pilocytic astrocytoma. Full staging was carried out that included imaging of the mind and cerebrospinal fluid cytology. No different tumor was discovered by these strategies. Postoperatively the affected person was handled with massive area spinal radiation and concurrent chemotherapy adopted by adjuvant chemotherapy. She has up to now been clinically and radiographically steady.
CONCLUSION: It is a uncommon case of an grownup with a number of spinal pilocytic astrocytomas in an intradural extramedullary location, sometimes the results of cerebrospinal fluid dissemination of neoplastic cells from a major intracranial tumor website (i.e. drop metastasis). No typical major tumor was recognized on this affected person, suggesting these tumors could come up from heterotopic gliomas.
PMID: 30092761 [PubMed – in process]