[An Autopsy Case of Meningoencephalitis and Cerebral Infarction that Developed with Ramsay Hunt Syndrome and Disseminated Herpes Zoster].
Mind Nerve. 2018 Mar;70(three):253-258
Authors: Yamashiro N, Nagasaka T, Ooishi N, Tsuchiya M, Takaki R, Kobayashi F, Shindo Okay, Takiyama Y
We report right here the scientific presentation and subsequent post-mortem of a 90-year-old man who developed small papules with ache and swelling in his proper ear. On admission, he exhibited proper facial nerve paralysis, neck stiffness and Kernig’s signal. The cell rely was elevated and the varicella-zoster virus-PCR was optimistic within the CSF. Mind magnetic resonance imaging confirmed hyperintense lesions within the left pons and left temporal lobe, in FLAIR photographs. We identified the affected person with Ramsay Hunt syndrome and meningoencephalitis as a consequence of varicella-zoster virus. Though the signs of meningitis improved following therapy with intravenous acyclovir (750 mg/day initially, raised to 1,125 mg/day), 16 days after admission, he died abruptly as a consequence of gastrointestinal hemorrhage. The post-mortem findings included lymphocytic infiltration of the leptomeninges and perivascular house of the cerebrum, and slight parenchyma within the left temporal lobe and insula, as the principle histological options. Encephalitis as a consequence of varicella zoster virus has been acknowledged as a vasculopathy affecting giant and small vessels. Pathological affirmation is uncommon in varicella zoster virus meningoencephalitis.
PMID: 29519969 [PubMed – indexed for MEDLINE]